Study On The Mechanism Of Neurensin1 In The Maintenance Of Social Memory

Social memory is the memory that humans or animals produce to other individuals in group activities.It is very important for individual survival,health and reproduction.The formation and maintenance of social memory requires the participation of a variety of proteins,which together promote the formation of a period of memory.Neurensin1(NRSN1)is a double transmembrane protein located on the organelle membrane.It has been reported to be related to the negative regulation of memory formation,but it’s role in the formation of social memory and the mechanism remain unclear.In this study,we combined with animal behavior,electrophysiology and molecular biology techniques to investigate these problems.We found that NRSN1 protein expression in the ventral hippocampus of mice was decreased after social stimulation,and this decrease disappeared after dorsal signal input was blocked.When we overexpressed NRSN1 protein in the ventral hippocampus,we found that mice had defects in long-term social memory and impaired long-term potentiation(LTP).We further found that these phenomena may be related to the decrease of Ca MKII activity and the impaired phosphorylation level of Glu A1-Ser831 site.Our work reveals the role of NRSN1 in the formation of social memory and its neural circuit and molecular mechanism,which provides an experimental and theoretical basis for the study of the internal mechanism of social memory maintenance.