Homology Analysis Of Auditory Region In Superior Temporal Gyrus Between Human And Monkey Based On Connectivity

Exploring the structure and function of the brain is a cutting-edge scientific problem,and analysing its workings and neural mechanisms contributes to the understanding of higher cognitive functions specific to humans and the therapeutic analysis of related brain diseases,while macaques are a natural transitional model for the study of humans,and it is becoming increasingly important to conduct research on comparative approaches between humans and macaques across species.The primate superior temporal gyrus is located in the superior temporal lobe.As the centre for processing auditory messages,the superior temporal gyrus damaged may lead to auditory aphasia or cause the seizures.Comparative imaging allows quantification of changes in the volume of brain structures between species and comparability of cortical areas in terms of connectivity between species.However,these quantitative analyses do not address areas related to auditory processing in the superior temporal gyrus.There are numerous studies on the function of the superior temporal gyrus in both species,but it is uncertain whether there are similarities in connectivity patterns between human and macaque auditory-related areas of the superior temporal gyrus,or whether the two species are homologous in the auditory information processing areas of the superior temporal gyrus.In this study,multimodal data from functional magnetic resonance imaging and diffusion tensor imaging were used to investigate cross-species homology between the two species.Connections between brain areas based on areas of interest and target areas were established,and the structural and functional connectivity patterns in the superior temporal gyrus of humans and macaques were investigated in depth using a comparative connectivity fingerprinting approach,and the results were finally statistically analysed using the permutation test.The results revealed that humans and macaques share similar structural and functional connectivity features in the auditory area of the superior temporal gyrus,and that the two species share a common evolutionary origin in the superior temporal gyrus.The research in this thesis was supported by the National Foundation of China and the provincial R&D programme,and the main components of the study are as follows.(1)To address the problem of differences in brain structure among subjects,this thesis chooses to extract areas of interest based on the individual level,combining linear alignment and non-linear alignment to align the brain atlas under the selected standard space to the individual,and then carry out the extraction of regions of interest.(2)To address the problem of cross-species structural homology,this thesis identifies regions of interest and target areas,and uses probabilistic fiber bundle tracking techniques to track human and macaque monkeys to establish connection fingerprints for similarity calculation.The connection fingerprint metric was then used as a test quantity for statistical analysis.Eventually,it was found that in the superior temporal gyrus,human area 38 m and macaque STGr,R,RT,and human area 22 c and macaque A1 were structurally homologous.(3)To address the issue of cross-species functional homology,this thesis uses resting-state functional MRI data to calculate the time series and corresponding Pearson correlation coefficients of the areas of interest in humans and macaques to obtain a functional connectivity matrix.The functional connectivity matrix was used to establish the connectivity fingerprints for similarity calculation.The results were then statistically analysed using the permutation test,which finally revealed that in the superior temporal gyrus,human area 38 l and macaque STGr,human area 22 c and macaque A1,and human area TE and macaque R and RT were functionally homologous.