Cardiac Cycle Synchronization Based On Optical Coherence Tomography

Congenital heart disease is one of the most important diseases that endanger human health.Studies have shown that in the early stages of embryonic development,blood flow affects the expression of vascular endothelial cells,which affects the structure and function of the heart.Abnormal blood flow may lead to diseases such as congenital heart defects,but the specific mechanism is not fully understood.In embryonic heart development research,avian embryos are commonly used animal models,and imaging and parameter measurement of the heart is a necessary condition for related research.However,early embryonic hearts are small and pulsating rapidly,and their imaging,especially three-dimensional imaging,is somewhat difficult.Optical Coherence Tomography(OCT)is an imaging method based on low coherence interference theory,which can image deep scattering in strong scattering media such as biological tissues.OCT technology has the advantages of fast acquisition speed,non-contact,non-invasive,high resolution and high sensitivity,which is very suitable for early embryo development research.The embryonic heart periodically beats and pumps out blood,which corresponds to its cyclical changes in bioimpedance.This paper combines OCT technology with bioimpedance signal measurement to achieve three-dimensional imaging of the early embryonic heart.The OCT technique performs four-dimensional(x,y,z,+t)scanning on the chicken embryo heart,and the data acquisition card synchronously collects the cardiac bioimpedance changes,and synchronizes the image acquired by the OCT through the impedance signal to realize the reconstruction of the instantaneous three-dimensional structure of the heart.This paper introduces the research significance of early cardiac detection and the development background of OCT technology.Through the research on the basic principles of OCT,a fast,high-resolution spectral OCT system is designed and built.The equivalent impedance model of biological tissue is expounded.The principle and matching method of impedance signal are introduced,and the impedance signal is trended.The system was used to image and reconstruct the embryonic heart of the sputum,and the instantaneous three-dimensional structure of the early embryonic heart at different beat phases was obtained.The Doppler angle of the blood flow was extracted based on the structure diagram,and the absolute flow velocity was calculated.