| 1.Clinical study of miao medicine black cane zhuifeng bone fluid insulation paper fire treatment of cancer-related fatigueObjective:To study the clinical efficacy and function value of miao medicine black cane zhuifeng bone fluid insulation paper fire intervention on the fatigue degree,quality of life,physical status,TCM symptom index and safety of patients with cancer-related fatigue.Methods:This study adopts a prospective randomized controlled trial method,60 patients with cancer-related fatigue were randomly divided into treatment group(n=30)and control group(n=30).Control group:routine treatment;Experimental group:control group was treated with miao medicine insulation paper fire therapy,once a day,7 times as a course of treatment,a total of 14 days.Before and after treatment,the two groups of patients were asked to fill in Piper fatigue scale,quality of life scale,KPS score scale,TCM symptom score scale and monitoring adverse reactions.The scores of the two groups before and after treatment were statistically analyzed to evaluate the efficacy and safety of miao medicine insulation paper fire in the treatment of cancer-related fatigue.Results:(1)Comparison of Piper fatigue scale score:There was no significant difference in the total score of fatigue,behavioral dimension,emotional dimension,sensory dimension and cognitive dimension between the two groups before treatment(P>0.05).After treatment,there were significant differences in the total score of fatigue,emotional dimension,sensory dimension and behavior dimension between the miao medicine group and the routine group(P<0.05),but there was no significant difference in the cognitive dimension(P>0.05).Comparison between the two groups:there were significant differences in the total score of fatigue,behavioral dimension,sensory dimension,emotional dimension and cognitive dimension in the miao medical group before and after treatment(P<0.05),which were lower than those in the routine group.There were significant differences in the total score of fatigue,behavioral dimension,emotional dimension,sensory dimension and cognitive dimension in the routine group before and after treatment(P<0.05).(2)Comparison of quality of life score:Comparison of functional scores:there was no significant difference in physical function,role function,cognitive function,emotional function,social function and overall quality of life between the two groups before treatment(P>0.05).There were significant differences in physical,emotional and overall scores after treatment in the miao medical group(P<0.05),and the score was higher than that in the routine group.The function and overall quality of life in the two groups before and after treatment were significantly higher than those before treatment(P<0.05).Comparison of symptom scores:there was no significant difference in fatigue,pain,nausea and vomiting between the two groups before treatment(P>0.05).The scores of fatigue,nausea and vomiting in the miao medical group were significantly lower than those in the routine group after treatment(P<0.05).The scores of fatigue,nausea and vomiting and pain in the routine group after treatment were significantly lower than those before treatment(P<0.05).Comparison of individual scores:there was no significant difference in shortness of breath,insomnia,loss of appetite,constipation,diarrhea and economic difficulties between the two groups before and after treatment(P>0.05),but there was significant difference in the scores of shortness of breath,insomnia and diarrhea between the two groups(P<0.05),and the scores after treatment were lower than those before treatment,but there was no significant difference in other individual scores(P>0.05).(3)Comparison of the symptom score of qi and blood deficiency:The score after treatment in the miao medical group and the routine group was lower than that before treatment,the difference was statistically significant(P<0.05).There was no significant difference in the syndrome score of qi and blood deficiency between the miao medical group and the routine group before treatment(P>0.05),but the score in the miao group was lower than that in the routine group after treatment.The difference was statistically significant(P<0.05).After treatment,the overall effective rate of the miao medical group was higher than that of the routine group,and the difference was statistically significant(P<0.05).(4)Comparison of KPS score:There was no significant difference in the score before treatment between the miao medical group and the routine group(P>0.05),but the score in the miao medical group after treatment was significantly higher than that in the routine group,and the difference was statistically significant(P<0.05).The scores in the miao Medical Group were higher than before the treatment,and the difference was statistically significant(P<0.05).The score in the routine group was not significantly higher than that before treatment,there was no significant difference(P>0.05).(5)Safety evaluation:Adverse reactions:l case of scald and 1 case of diarrhea were reported in Miao Medical Group.Laboratory indicators:blood routine,the WBC?HGB?PLT of the Miao group after treatment was not statistically significant compared with the conventional group(P>0.05);before and after treatment,the blood routine indicators were not statistically significant(P>0.05).There was no significant difference in liver and kidney function between ALT?AST?BUN?CREA and routine group(P>0.05).There was significant difference in AST?CREA before and after treatment(P<0.05)were not statistically significant(P>0.05).Conclusion:Miao medicine black cane zhuifeng bone fluid insulation paper fire can effectively relieve the fatigue degree of patients with cancer-related fatigue,improve the quality of life and physical condition of patients,improve the symptoms of deficiency of qi and blood,comprehensively improve the quality of life of tumor patients and reduce tiredness.there are no obvious adverse reactions,the curative effect is good,relatively safe,and has a certain value of promotion.2.Study on the medication regularity of traditional Chinese medicine compound prescription compound in the treatment of cancer-related fatigue based on the Ancient and Modern Consilia Cloud PlatformObjective:To explore the clinical medication regularity and characteristics of the traditional Chinese medicine compound prescription compound for the treatment of cancer-related fatigue based on the ancient and Ancient and Modern Consilia Cloud Platform.Methods:Collect and sort out the literature of traditional Chinese medicine compound prescription compound intervention cancer-related fatigue network database,and use the Ancient and Modern Consilia Cloud Platform V2.1 developed by the Research Institute of Chinese Academy of traditional Chinese Medicine to mine the drugs,analyze the main drugs and get the clinical characteristics of traditional Chinese medicine compound prescription compound in the treatment of cancer-related fatigue.Results:(1)A total of 186 prescriptions were included.(2)Through the analysis of drug frequency,it can be concluded that the top five drugs are Atractylodes macrocephala,Radix Astragali,Poria cocos,Angelica sinensis and Codonopsis pilosula.(3)Application of drug association method,the top five drugs combinations are"Poria cocos,Atractylodes macrocephala","Astragalus membranaceus,Atractylodes macrocephala","Poria cocos,Atractylodes macrocephala","Angelica sinensis,Atractylodes macrocephala".(4)Through the attribute analysis of traditional Chinese Medicine,it is concluded that the top 5 of the four properties are "warm,flat,lukewarm,slightly cold and cold",and the top 5 of the five flavors are "sweet,pungent,bitter,sour and light".The top five channel tropisms are "spleen,lung,liver,stomach,heart".(5)Through the cluster method in multidimensional analysis,the first 30 medicines with frequency more than 16 times can be divided into three categories,the first category is Angelica sinensis,licorice,astragalus,Atractylodes macrocephala,Poria cocos;the second category:Chinese yam,Coix seed,Bupleurum,ginseng,Radix Glycyrrhizae Preparata,Radix Paeoniae Alba;the third group can be divided into two groups,one group is Codonopsis pilosula,tangerine peel,malt,Hawthorn,medicated leaven,and another groups is Chinese wolfberry,Radix Rehmanniae,Cornus officinalis.(6)Finally,through the complex network analysis in multidimensional analysis,it is concluded that the core drugs is 18 flavors,and the thinking of prescription is Bazhen decoction,Sini San,Jianpi pill add or subtract.Conclusion:Traditional Chinese medicine compound prescription for the treatment of cancer-related fatigue is mainly used to enrich blood and Supplement qi,nourish yin and support yang,and strengthen the body to fight cancer.At the same time,take care of spleen and kidney essence qi,medication both lung,heart,liver,so that the medicine reaches each disease without neglecting one,reviving essence,qi,blood and body fluid.The rule of medication shows that traditional Chinese medicine can help to improve the immunity of cancer patients,alleviate fatigue symptoms and improve their quality of life.3.Meta analysis of clinical effect of moxibustion on cancer-related fatigueObjective:To evaluate the clinical efficacy of moxibustion in the treatment of cancer-related fatigue in cancer patients.Methods:Search Chinese and English database,example China national knowledge intemet(CNKI),WanFang database,Chongqing VIP database,PubMed,Embase and Cochrane Library,and collect randomized controlled trials from 2000 to 2018.Systematic evaluation was conducted from Piper score,BFI score,KPS score,EORTC QLQ-C30 quality of life score and blood routine as evaluation indicators.RevMan5.3 software is used to analyze and evaluate the literature quality through the above indicators.Finally,publication bias and heterogeneity analysis are analyzed.Results:(1)A total of 20 articles were included in this study.Moxibustion(unlimited type)was used as intervention measures in the treatment group,including combined music and systematic nursing,while routine nursing and symptomatic treatment were used in the control group,to evaluate the clinical efficacy of moxibustion in improving cancer-related fatigue.(2)According to the literature percentage map to evaluate the literature quality,the data of 20 literatures are relatively complete and the overall quality is low.The blind method has a high risk of bias,as well as the method of random sequence,the hidden description of distribution is unclear,selective report bias and other bias risks are not mentioned in the articles.The quality of the included literature is not high and the risk of bias is high.(3)The results of Piper score analysis showed that there was a statistical difference between the two groups,and the results showed that[MD=-1.14(95%CI:[-1.63,-0.65]),Z=4.56,P<0.00001].The analysis of BFI score showed that[MD=-2.2(95%CI[-2.85,-1.55]),Z=6.61,P<0.00001],the difference was statistically significant.The comparison of KPS score showed that[MD=12.31(95%CI[9.39,15.23]),Z=8.27,P<0.00001<0.05]and the performance status of the patients in the two groups was statistically significant.Comparison of the quality of life score,the analysis showed that[MD=8.90(95%CI[3.68,14.12]),Z=3.34,P=0.0008<0.05].There was relative statistical significance in the quality of life score between the two groups after treatment.The blood routine indexes of the two groups were analyzed together,and the overall results showed that[MD=0.29(95%CI[-0.17,0.74]),Z=1.23,P=0.22>0.05],the overall difference was not statistically significant.The results of leukocyte showed that[MD=0.62(95%CI[0.13,1.11]),Z=2.49,P=0.01<0.05],the difference is statistically significant.The results of platelets shows that[MD=33.04(95%CI[15.53,55.55]),Z=3.7,P=0.0002<0.05],the difference was statistically significant.The hemoglobin results showed that[MD=3.03(95%CI[-3.43,9.49]),Z=0.92,P=0.36>0.05],and the difference was not statistically significant.The results of neutrophils showed that[MD=-0.90(95%CI[-1.42,-0.38]),Z=3.40,P=0.0007<0.05],and the difference was statistically significant.The results of lymphocytes showed that[MD=0.45(95%CI[-0.14,1.03]),Z=1.49,P=0.14>0.05],there was no significant difference.(4)The funnel plot shows left and right asymmetry,concentrated overlap at the top,the point on the left is beyond the confidence interval,considering that the quality of the included literature is low,the overall study is heterogeneous,and there may be a large publication bias.Conclusion:Generally speaking,moxibustion can effectively improve the fatigue and performance status of cancer-related fatigue patients.In addition,it can also improve the quality of life and improve the levels of leukocytes,platelets and neutrophils. |
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