| Objective:The purpose of this study was to investigate the clinical efficacy and safety of "Zhi Tong An Cha Ji" fumigation and sitting bath in the application of mixed hemorrhoids.Through this research,a safer,more convenient and effective treatment plan is provided for postoperative treatment of mixed hemorrhoids.Methods:In this study,100 inpatients who received Milligan-Morgan hemorrhodectomy from the anorectal disease area of the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from January 2019 to December 2019 were selected.Patients who meet the diagnosis,inclusion criteria and agree to sign into the group are included in this research.According to the patient's admission order and random number table method,they were randomly divided into treatment group(Zhi Tong An Cha Ji)50 cases and control group(Jin Xuan Zhi Ke Xun Xi San)50 cases.Both groups of patients were given postoperative hemostasis,nutritional support and wound dressing changes.After defecation on the first day after operation,the treatment group was fumigated by Zhi Tong An Cha Ji and the control group was fumigated by Jin Xuan Zhi Ke Xun Xi San.The wound pain,edema,granulation shape symptom scores were recorded on the 3rd,7th and 14th day after surgery,and the wound healing rate was calculated according to the wound area and related formulas.On the 7th day after surgery,part of the wound granulation tissue was excised from the patients in the Zhi Tong An Cha Ji group and Jin Xuan Zhi Ke Xun Xi San group,and the contents of MMP-9 and HYP were determined.At 14 days after surgery,the overall efficacy,adverse reactions,and safety of the two groups were evaluated.Results:1.Wound pain:On day 3,the wound pain scores of the two groups of subjects were compared(P<0.05),and the difference was significant.It was proved that the overall efficacy of topical "Zhi Tong An Cha Ji" in the treatment group was better than that of the control group on the third day;there was no statistical difference in wound pain score analysis on the 7th and 14th days after operation(P>0.05).Subjects' pain levels were significantly less than before.2.Wound edema:On the 3rd and 7th days,the score of wound edema was compared between the two groups of subjects(P<0.05),and the difference was significant.It showed that the treatment group treated with "Zhi Tong An Cha Ji" on the 3rd day and the 7th day had a better effect than the control group;the score of wound edema on the 14th day after surgery was not clinically significant(P>0.05).The external application of "Zhi Tong An Cha Ji" on the 14th day after surgery had no difference in reducing wound edema compared with the control group,and the edema in both groups was significantly improved.3.Granulation morphology:On day 3,the wound granulation growth scores of the two groups of subjects were compared,and there was no statistical difference(P>0.05).On the 7th and 14th days after surgery,the granulation morphology scores of the two groups were significantly different(P<0.05).It was proved that the external effect of "Zhi Tong An Cha Ji" in the treatment group on the 7th and 14th days was better than that of the control group in accelerating granulation.4.Wound healing rate:There was no difference in the wound healing rate score between the two groups of subjects on the 3rd day(P>0.05).It was confirmed that the treatment group given "Zhi Tong An Cha Ji" on the third day after surgery had no difference from the control group in accelerating wound healing.There were no differences in groups.However,the wound healing rate scores of the two groups of subjects on the 7th day and the 14th day were compared(P<0.05),indicating that the treatment group received "Zhi Tong An Cha Ji" on the 7th and 14th days to accelerate the healing effect Better than the control group.5.HYP content in granulation tissue on day 7:At 1 week after operation,the HYP content data of the two groups of subjects were compared with each other and there was a significant difference(P<0.05).6.MMP-9 content in granulation tissue on day 7:At 1 week after surgery,there was a significant difference between the data of MMP-9 content in the two groups of subjects(P<0.05).Conclusion:Clinical studies have confirmed that the use of "Zhi Tong An Cha Ji" in patients with Milligan-Morgan hemorrhodectomy can effectively relieve anal pain,reduce edema in the surgical area,and accelerate wound healing.No toxic side effects and adverse reactions,safe and effective. |
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