Study On The Prescription Rules Of Traditional Chinese Medicine For Breast Cancer Caused By Endocrine Drugs

Purpose:Published by collecting 2005-2020 lead to adverse reactions of traditional Chinese medicine treatment of breast cancer endocrine drugs the clinical application of relevant literature,analysis of traditional Chinese medicine(TCM)in improving the sent the regularity of endocrine therapy of breast cancer cause adverse reactions;Combined with the data mining method to analyze the conditions of drug utilization of the literature,to explore Chinese medicine treatment of breast cancer endocrine drug adverse reactions caused by drug use;And the method based on network pharmacology exploring by high-frequency Chinese medicine radix bupleuri,radix paeoniae alba medicine in the treatment of breast cancer may function targets and pathways,for clinical reasonable select the clinical and experimental research to provide theoretical support.Material and method:The method of using electronic retrieval,search on CNKI in 2005-2020 published about traditional Chinese medicine clinical application in endocrine therapy of breast cancer related literature.Intensive reading literature,use EXCEL to include basic information,disease information of literature and medicine information carries on the preliminary sorting and statistics,from on macroscopic to explore traditional Chinese medicine(TCM)in improving the clinical application of endocrine therapy in breast cancer cause adverse reactions of sent the law;Using EXCEL to document frequency of drugs,medicines sexual flavour to the statistics and analysis,such as using SPSS18.0,SPSS Modeler18 high-frequency medicines for clustering analysis,aiming at a common endocrine therapy of breast cancer in clinical perimenopausal syndrome,caused by bone metabolic abnormalities and dyslipidemia of traditional Chinese medicine prescription for correlation analysis,to explore Chinese medicine treatment of breast cancer endocrine drug laws and characteristics of adverse reactions of medication;Using the method of network pharmacology analysis of radix bupleuri,radix paeoniae alba in the treatment of breast cancer related targets and possible pathways.Results: 1 This research into traditional Chinese medicine treatment of breast cancer endocrine drugs lead to adverse reactions of literature,a total of 87 articles published between 2005-2020.According to evidence-based medical evidence classification,64 pieces of literature can be divided into class II,III grade 21,V level 2,involved in traditional Chinese medicine treatment of breast cancer endocrine drug adverse reaction caused by mainly kind of perimenopausal syndrome,fatigue syndrome,abnormal bone metabolism,dyslipidemia,and endometrial thickening.Caused by involved in traditional Chinese medicine treatment of endocrine drug class related literature of the menopausal transition,and endocrine drug class mechanism of perimenopausal syndrome and clinical manifestations of complicated,will cause the endocrine drug class further subdivided into: perimenopausal syndrome is given priority to with hot flashes night sweats syndrome,mainly of modern abnormal syndrome,mainly gastrointestinal syndrome and give priority to with palpitations insomnia syndrome.2 In traditional Chinese medicine treatment of breast cancer endocrine drugs lead to such aspects: perimenopausal syndrome involves class II 40 references related to level 1,level III 16 papers and V,containing a total of 4426 cases,the Chinese medicine treatment effective rate was 93.35%;Is given priority to with hot flashes night sweats syndrome treatment with liuwei dihuang pill,black xiaoyao powder,2 more fairy,such as soup,nourishing liver and kidney of classical prescription to add and subtract the cutting is given priority to,combined with professor Huang Huang typhoid ten kinds of theory,such prescriptions as part of the cultivated land;Mainly of modern abnormal syndrome treatment is given priority to with xiaoyao powder,cutting,radix bupleuri class party;Mainly gastrointestinal syndrome of traditional Chinese medicine treatment is given priority to with four gentlemen tonga to simplify and cutting,astragalus membranaceus class party;Is given priority to with palpitations insomnia syndrome of traditional Chinese medicine treatment of spleen-invigorating soup or pop bushing Dan cutting is given priority to add and subtract.3 In traditional Chinese medicine treatment of breast cancer bone metabolic abnormalities caused by endocrine drugs in clinical applications,involving the class II 6 references,level III article 1,294 cases,the effective rate was 70.00%;Treatment on pill with left or right to pill more add and subtract the cutting is given priority to,cultivated land class party.4 Lead to fatigue syndrome in traditional Chinese medicine treatment of breast cancer endocrine drugs clinical applications,involving literature class II grade 12,3 a level III and V article 1 article,include cases of 529 cases,the Chinese medicine treatment effective rate was 76.46%;Treatment is given priority to with four gentlemen tonga to simplify and cutting,astragalus membranaceus class party;5 In traditional Chinese medicine treatment of breast cancer endocrine drugs in the clinical application of dyslipidemia,covered with class II 3 references,58 cases,the effective rate was 75.10%.Treatment on how to make up for in yiqi tonga,reducing cutting is given priority to,belong to the root of remembranous milk vetch class party.6 In traditional Chinese medicine treatment of breast cancer endocrine drugs lead to the clinical application of endometrial thickening,involving the class II 2 references,Chinese medicine treatment effective rate of 89.34%,medicine how to add and subtract on the basis of two to pill.7 Improve the endocrine therapy of breast cancer in Chinese medicine literature,the clinical application of lead to adverse reactions in patients with clinical stage II-III,pathological classification is given priority to with infiltrating ductal carcinoma,presumably with clinical stage II-phase III clinical and pathological classification of infiltrating ductal carcinoma of breast cancer patients,there is no exact clinical evidence confirmed that Chinese medicine treatment the curative effect of breast cancer inside cent secret drug lead to adverse reactions and breast cancer patients with clinical stage and pathological classification.8 Involved drug efficacy results: a total of 18 categories,in the majority with tonify deficiency,clear heat and promoting blood circulation to remove blood stasis drugs.Functions further analysis: the traditional Chinese medicine involved 39 small categories,with Yang,heat-clearing and detoxicating and Yin tonic medicine in the majority.Four aspects: cold sex medicine the most,followed by warm medicine;Five aspects: the most adjuvant,bitter taste and flavour.Owned by the aspects: the liver meridian medicine the most,followed by the lung,spleen,kidney.Use frequency of the top five of TCM are: poria cocos,atractylodes,radix glycyrrhizae,radix bupleuri,radix paeoniae alba,poria cocos,use frequency is highest,is 57.9 On 20 TCM before drug use frequency of system clustering analysis: for different class with WARD method,the distance between the measurement distance index selection Euclidean distance square,when the intercept is 20,is 5 class clustering effect is better.Respectively is: class 1: rhizoma anemarrhenae cortex phellodendri---a fairy curculigo spleen;Class 2:licorice,Chinese angelica,poria cocos,atractylodes,radix bupleuri,radix paeoniae alba,radix curcumae,fructus ligustri lucidi.Class 3;Medlar.Class 4: yam-alisma-mountain cornus-cultivated land-cortex moutan;Class 5: astragalus codonopsis.10 On IBM SPSS Modeler18.0 software aimed at to treat breast cancer endocrine drug class perimenopausal syndrome of traditional Chinese medicine prescription for correlation analysis,it is concluded that to support the percentage from high to low arrangement on the basis of former three combinations are: radix bupleuri-root of herbaceous peony;Radix bupleuri-poria cocos;Atractylodes poria cocos,support in the order: 47.27%,47.27% and 45.25% [note: the support representative referred to in the preceding paragraph and the probability of consequent drugs appeared at the same time,such as radix bupleuri,radix paeoniae alba support was 47.27%,the confidence level of 84.62%,on behalf of radix bupleuri and radix paeoniae alba and a probability of 47.27%].11 On IBM SPSS Modeler18.0 software to give priority to in order to treat breast cancer endocrine drugs cause bone metabolic abnormalities of traditional Chinese medicine prescription for correlation analysis,it is concluded that to support the highest percentage of two drug combinations are: yam-rehmannia glutinosa and yam-atractylodes,support degree is 47.27%.12 On IBM SPSS Modeler18.0 software for mainly for breast cancer endocrine drugs cause dyslipidemia of traditional Chinese medicine prescription for correlation analysis,core drug combination for astragalus radix bupleuri-poria cocos-[note: due to insufficient sample,carries on the correlation analysis of support does not have specificity,radix bupleuri,poria cocos-the root of remembranous milk vetch is according to the correlation analysis network diagram intuitive clear it is concluded that the core of the drug combination].13 GO biological process of enrichment and KEGG pathway enrichment analysis results in radix bupleuri,radix paeoniae alba may by adjusting TNFSF15,RUNX1T1,PPARD,ELK1,EIF6 targets,such as regulation of TNF,IL-17,HIF-1,Toll-like receptor signaling pathways such as restrain the progress of breast cancer.Conclusion: 1 Traditional Chinese medicine to improve adverse reaction is mainly caused by endocrine therapy of breast cancer as the kind of perimenopausal syndrome,abnormal bone metabolism,endometrial thickening,fatigue syndrome,and dyslipidemia,caused by endocrine therapy clinical common types of perimenopausal syndrome,and can be further divided into to digestive discomfort(loose stools,stay,nausea,etc.)mainly syndrome,mainly of modern abnormal syndrome,syndrome of the mainly hot flashes night sweats and predominantly palpitations insomnia syndrome;2 Endocrine drug adverse reaction caused by traditional Chinese medicine in the treatment of breast cancer,many with nourishing liver and kidney,replenishing qi spleen and qi as the main treatment;In addition also compatibility qingrejiedu,eliminating phlegm to fights the traditional Chinese medicine to assist in endocrine drugs to inhibit the progress of the breast cancer.3 Based on clustering analysis and association rules to explore TCM drug laws in endocrine therapy of breast cancer Rhizoma anemarrhenae cortex phellodendri---a fairy curculigo spleen: endocrine drugs can be used in the treatment of breast cancer patients after caused by bone metabolic abnormalities,compatibility of other nourishing liver and kidney or liver resolve depression drugs can be used to treat breast cancer patients caused by endocrine drugs type perimenopausal syndrome.Licorice,Chinese angelica,poria cocos,atractylodes,radix bupleuri,radix paeoniae alba,radix curcumae,fructus ligustri lucidi: clinical endocrine drugs can be used in the treatment of breast cancer patients after appearing is given priority to with mood disorders syndrome type of perimenopausal syndrome.Another class 2 medicine group network diagram contains the association rules it is concluded that the core of the drug combination(radix bupleuri radix paeoniae alba,radix glycyrrhizae-atractylodes poria cocos-angelica),also verify the formula in the current into the literature contains more easy adjustment.Medlar: compatibility of other drugs to improve endocrine therapy of breast cancer caused by a variety of adverse reactions of traditional Chinese medicine prescriptions.Yam-alisma-mountain cornus-prepared rhizome of rehmannia,cortex moutan: can use endocrine drugs used to treat breast cancer patients,there is given priority to with hot flashes night sweats syndrome type of perimenopausal syndrome.Astragalus,codonopsis,can be used to improve breast cancer patients after endocrine therapy of cancer-related fatigue formula.4 Radix bupleuri,radix paeoniae alba could adjust the TNFSF15,RUNX1T1,PPARD,ELK1,EIF6 targets,such as regulation of TNF,IL-17,HIF-1,Toll-like receptor signaling pathways such as inhibition of breast cancer are reviewed.The molecular mechanism of the treatment of breast cancer cells may be related to chemical stress reaction,cell chemical stress response,reactive oxygen species,oxidative stress,the development of gland,etc.