Study On The Risk Factors Of Type 2 Diabetes Mellitus Complicated With Hyperuricemia And Its TCM Syndrome Differentiation

Objective:To explore the risk factors of type 2 diabetes mellitus complicated with hyperuricemia,analyze its correlation with clinical indicators,and carry out syndrome differentiation from the perspective of traditional Chinese medicine,so as to provide help for clinical diagnosis and treatment.Materials and methods:from February 2020 to October 2021,326 patients with type 2diabetes were admitted to Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.According to the results of serum uric acid,they were divided into type 2 diabetes mellitus without hyperuricemia group(group A)and type 2diabetes complicated with hyperuricemia group(group B),including 218 cases in group A and 108 cases in B group.Gender,age,course of disease,body mass index(BMI),waist circumference(WC),systolic blood pressure(SBP),diastolic blood pressure(DBP),clinical symptoms,tongue and pulse of the two groups were collected.5ml of fasting venous blood was collected for laboratory test,and total cholesterol(TC)in serum was detected,TC,triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),glycosylated hemoglobin(HbA1c),fasting blood glucose(fasting blood glucose)plasma Fasting glucose(FPG),serum creatinine(SCr)and 2-hour postprandial glucose(2hPG)were measured.According to the standard of TCM syndrome differentiation,it can be divided into six syndrome types:deficiency of both qi and Yin,deficiency of both qi and blood stasis,deficiency of both yin and Yang,deficiency of both yin and Yang and blood stasis,dampness heat trapping spleen,dampness heat trapping spleen and blood stasis.result:1.Comparison of general conditions between the two groups.There was no significant difference in gender distribution and course of disease between the two groups(P>0.05);The age of patients in group B was(43.63±7.91)years was lower than that in group A(58.87±8.15)years,The difference was statistically significant(P<0.05).2.Comparison of BMI and waist circumference between the two groups The BMI and WC of group B were(27.78±2.22)kg/m~2and(83.94±5.03)cm was significantly higher than that in group A(25.37±2.18)kg/m~2and(76.88±4.04)cm,the difference was statistically significant(P<0.05).3.Comparison of blood pressure between the two groupsThe DBP of group B was(90.98±9.91)mm Hg was significantly higher than that in group A(78.32±9.89)mm Hg,the difference was statistically significant(P<0.05).4.Comparison of blood glucose levels between the two groupsThere was no significant difference in FPG,2hPG and HbA1c levels between the two groups(P>0.05).5.Comparison of blood lipid level between the two groupsThere was no significant difference in the levels of TC and LDL-C between group B and group A(P>0.05);TG level of group B was higher than that of group A,HDL-C level was lower than that of group A,the difference was statistically significant(P<0.05).6.Comparison of serum creatinine levels between the two groupsSCr in group B was(77.87±21.12)?mol/L The level of serum creatinine in group A was significantly higher than that in group A(67.82±20.76)?mol/L The difference was statistically significant(P<0.05).7.Comparison of complications between the two groupsThe proportion of hypertension and coronary heart disease in group B was higher than that in group A(P<0.05).8.Logistic regression analysis of hyperuricemia in type 2 diabetes mellitusLogistic regression analysis of age,BMI,body weight,DBP,SBP,TG,HDL-C and SCr showed that age and body weight were risk factors for type 2 diabetes mellitus complicated with hyperuricemia(P<0.05).9.Distribution of TCM syndrome differentiation in two groupsIn group B,deficiency of both qi and Yin,deficiency of both yin and Yang,dampness and heat trapping spleen syndrome accounted for more,the difference was statistically significant(P<0.05),but there was no significant difference in group A.Conclusion1.Age and weight were risk factors for hyperuricemia in type 2 diabetes mellitus,suggesting that serum uric acid levels should be monitored in obese and young patients with type 2diabetes.2.Type 2 diabetes mellitus complicated with hyperuricemia patients have higher prevalence of hypertension and coronary heart disease.3.Type 2 diabetes mellitus complicated with hyperuricemia is associated with increased diastolic blood pressure and hypertriglyceridemia.4.Type 2 diabetes mellitus complicated with hyperuricemia,there are three types of syndromes:deficiency of Qi and Yin,phlegm dampness and spleen deficiency,yin and yang two deficiency.