A Study On Related Risk Factors And TCM Syndrome Types Of Type 2 Diabetes Mellitus Complicated With Chronic Kidney Disease

Purpose:This study compares the clinical metabolic indicators of patients with type 2diabetes(T2DM)combined with chronic kidney disease(CKD)and patients without CKD,and analyzes the T2DM combined with CKD patients'TCM syndromes,and explores the related risk factors and T2DM syndromes of T2DM with CKD.The distribution situation provides an objective basis for further prevention and control.Material and method:This article analyzes 414 T2DM patients who met the inclusion criteria in the Endocrinology Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from December 2019 to November 2020.Among them,there were 212 cases in the T2DM-free CKD group(T2DM group)and T2DM combined with CKD group(referred to as the T2DM+CKD group)202 cases.Collect clinical information of patients,including:gender,age,course of disease,smoking history,drinking history,body mass index(BMI),waist circumference(WC),blood pressure,glucose metabolism index,lipid metabolism index,renal function related index;whether it is accompanied by diabetes Retinopathy(DR),diabetic peripheral neuropathy(DPN),atherosclerosis(AS),coronary heart disease,fatty liver and other comorbidities;TCM symptoms and tongue coating and pulse conditions.The T2DM+CKD component is divided into four TCM syndrome types:Yin deficiency and dry heat syndrome,Qi and Yin deficiency syndrome,Spleen and Kidney Qi deficiency syndrome,Yin and Yang deficiency syndrome,according to the scheme formulated by the Nephropathy Branch of the Chinese Society of Traditional Chinese Medicine in 2007.Develop an observation Excel database,apply statistical software SPSS26.0 for data analysis,measure data with`x±s,use independent sample test for normal distribution between two groups,and use single factor for normal distribution and homogeneity of variances between two groups Analysis of variance,non-parametric test is used for non-conformities;count data is represented by n(%),and?~2test is used.Logistic regression was used to analyze the related risk factors of T2DM combined with CKD,and the distribution of T2DM combined with CKD and the correlation between T2DM and CKD syndrome types and various factors were analyzed.P<0.05 indicates statistical significance.Results:1.Comparison of the general conditions of the two groups:the age,course of disease,waist circumference,and systolic blood pressure in the T2DM+CKD group were greater than those in the T2DM group,and the results were statistically significant(P<0.05);the gender,smoking history,drinking history,body mass index,There was no significant difference in diastolic blood pressure(P>0.05).2.Comparison of laboratory indicators between the two groups:FPG,TG,UA and SCr in the T2DM+CKD group were higher than those in the T2DM group,and e GFR was lower than the T2DM group(P<0.05);There was no significant difference in Hb A1c,FCP,TC,HDL-C,LDL-C(P>0.05).3.Comparison of comorbidities between the two groups:Compared with the T2DM group,the proportion of T2DM+CKD combined with DR,DPN,and coronary heart disease increased,and the difference was statistically significant(P<0.05);the two groups of patients had AS and fatty liver There was no significant difference in the situation(P>0.05).4.Analysis of risk factors in T2DM+CKD group:Logistic regression analysis showed that age,course of disease,SBP,UA,combined DR,combined with coronary heart disease were the main risk factors for T2DM combined with CKD(P<0.05).5.T2DM+CKD group TCM syndrome distribution characteristics:93 cases of Qi and Yin deficiency(46.04%)>42 cases of Yin deficiency and dry heat syndrome(20.79%)>39 cases of Spleen and Kidney Qi deficiency(19.31%)>Yin and Yang deficiency syndrome 28 cases(13.86%).6.T2DM+CKD group T2DM+CKD group TCM syndrome type and various factors:Yin and Yang deficiency syndrome age,course of disease,SCr higher than Yin deficiency and dry heat syndrome,Qi and Yin deficiency syndrome and Spleen and Kidney Qi deficiency syndrome(P<0.05);Yin and Yang deficiency The SBP of Yin and Yang deficiency syndrome was higher than that of Yin deficiency and dry heat syndrome(P<0.05);the e GFR of Yin and Yang deficiency syndrome was lower than that of Yin deficiency and dry heat syndrome,Qi and Yin deficiency syndrome,and Spleen and Kidney Qi deficiency syndrome.The results were statistically significant(P<0.05).Conclusion:1.T2DM patients with CKD are older,have a longer course of diabetes,have a high proportion of hypertension,DR,DPN,and coronary heart disease.2.T2DM combined with CKD TCM syndrome distribution characteristics:Qi and Yin deficiency syndrome>Yin deficiency and dry heat syndrome>Spleen and kidney Qi deficiency syndrome>Yin and Yang deficiency syndrome.Deficiency of both qi and yin is the most common T2DM syndrome with CKD.The deficiency of both yin and yang may be more affected by age and the course of diabetes.3.Hypertension,hyperuricemia,combined with DR,combined with coronary heart disease may be the main risk factors for the development of T2DM combined with CKD.