Clinical Observation Of The Correlation Between IL-1R1-related Factors And Their Single Nucleotide Polymorphisms And Coronary Heart Disease In Chinese Han Population

Background: While increased expression of soluble CD121a(Interleukin 1Receptor Type 1,IL-1R1)has been shown to be significantly correlated with the severity of coronary artery disease(CAD),it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis.Methods: The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population;A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis.The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction(PCR)assay and directly sequenced.Results: The IL-1R1 single nucleotide polymorphism(SNP)rs2234651 was found to be associated with both CAD risk and severity.Furthermore,significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed.Logistic regression analysis results also suggested that this SNP is likely an indicator of CAD.Finally,serum CD121 a levels significantly increased in patients with CAD that harbored a TT genotype in variant rs2234651(P <0.05).Conclusions: These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be an invaluable novel target for CAD prevention and/or treatment.Background: Interleukin-1 receptor type I(IL-1R1)activates inflammatory signaling pathways that contribute to the progression and poor outcome of coronary artery diseases(CAD).However,its clinical utility is limited owing to low plasma levels.Although its soluble form CD121 a has identical binding affinity to the ligand,the prognostic value of serum CD121 a in patients with CAD has not been investigated.Methods: We enrolled 534 CAD patients in a prospective cohort study and explored the association of CD121 a with CAD outcomes using multivariate Cox proportional hazards analysis.Results:Patients with CD121 a ? 2425 pg/ml were more likely to be older,and to have higher cardiac troponin I,myoglobin,high-sensitivity C-reactive protein levels,histories of hypertension and stent implantation.Kaplan-Meier survival curves indicated that patients with CD121 a levels above 2425 pg/ml had a higher incidence of major adverse cardiac events(MACE)and acute coronary syndrome(ACS)compared with those whose CD121 a levels were below 2425 pg/ml.Multivariate Cox regression analysis suggested CD121 a as an independent predictor of MACE in CAD patients(HR: 2.697;95% CI: 1.385-5.253;P = 0.004);the same associations were observed in female patients(HR: 6.148;95% CI: 1.883–20.072;P = 0.003).Conclusions: CD121 a can be a valuable prognostic marker of MACE in patients with CAD,especially in female patients,independent of established conventional risk factors.