Correlation Analysis Of TCM Syndrome Distribution And Blood Biochemical Indexes In Hypertensive Cerebral Small Vessel Disease

Objective:Through the statistical investigation of the clinical data of patients with hypertensive cerebral small vessel disease,this paper analyzes the distribution characteristics of TCM syndrome types of patients with hypertensive cerebral small vessel disease,and the correlation between Hcy,blood lipid,renal function,FIB and TCM syndrome types,so as to provide theoretical basis for clinical syndrome differentiation and treatment of hypertensive cerebral small vessel disease.Methods:165 patients with cerebral small vessel disease and hypertension were included from June 1,2020 to March 1,2021 in the first Department of encephalopathy and physical examination department of the First Affiliated Hospital of Hunan University of traditional Chinese medicine.Collect the general disease information including symptoms,tongue and pulse.Through referring to the clinical guiding principles of new drugs of traditional Chinese medicine,combined with clinical practice,the TCM syndrome types of patients with hypertensive cerebral small vessel disease were classified into five groups including phlegm dampness syndrome,yin deficiency and yang hyperactivity syndrome,Qi and blood deficiency syndrome,liver fire hyperactivity syndrome,blood stasis obstructing collaterals syndrome.At last,collect height,weight and the relevant blood biochemical indexes(Hcy,blood lipid,renal function,FIB)data of every patients and use SPSS software to statistic analyze.Results:?Among the patients,male accounted for 60.2%and female accounted for 65.8%.The proportion of male patients under 60 years old is higher than that of female patients,and the proportion of female patients between 60 and 75 years old is significantly higher than that of male patients.?The proportion of TCM syndrome types of 165 patients with hypertensive cerebral small vessel disease from large to small was as follows:phlegm dampness syndrome(23.6%),yin deficiency and yang hyperactivity syndrome(21.2%),Qi and blood deficiency syndrome(19.4%),liver fire hyperactivity syndrome(18.2%),blood stasis obstructing collaterals syndrome(17.6%).?There was no significant difference in the course of hypertension,comorbidity,height,blood lipid(TC,TG,LDL-C,HDL-C),FIB,bun,GFR,UA levels between the two groups.?Most patients with hypertensive cerebral small vessel disease were complicated with hyperlipidemia,but there was no significant difference with gender(P>0.05).Most of the patients aged 60-75 years were complicated with coronary heart disease,diabetes and hyperlipidemia.?There were significant differences in BMI and body weight among TCM syndromes(P<0.05).The BMI and body weight of phlegm dampness excess syndrome were significantly higher than those of other syndromes.?There were significant differences in CR between phlegm dampness excess syndrome group and yin deficiency yang hyperactivity syndrome group,blood stasis syndrome group,Qi and blood deficiency syndrome group(P<0.05).?There was significant difference in Hcy level among TCM syndromes(P<0.05).The Hcy level of phlegm dampness excess syndrome and blood stasis obstructing collaterals syndrome was significantly higher than that of other syndrome types,and the Hcy level of Qi blood deficiency syndrome was significantly lower than that of other syndrome types.Conclusion:There is a certain rule in TCM syndrome differentiation of hypertensive cerebral small vessel disease,and the distribution ratio from high to low is phlegm dampness syndrome,yin deficiency and yang hyperactivity syndrome,Qi and blood deficiency syndrome,liver fire hyperactivity syndrome,blood stasis obstructing collaterals syndrome.There is a certain correlation between TCM syndrome differentiation and BMI,body weight,Cr,Hcy levels,which can be used as a reference index for TCM syndrome differentiation and treatment of hypertensive cerebral small vessel disease.