Evaluation Of Blood Stasis Syndrome In Acute Ischemic Stroke

Objective.The superior index of blood stasis syndrome evaluation in the acute phase of ischemic stroke is explored,so that the model of basic research syndrome is guided,and the objective development of TCM syndrome of blood stasis syndrome is promoted.Methods.This research was conducted in-depth through three parts.Part 1.RCTs of Ischemic stroke(IS)treated by Traditional Chinese Medicine were searched through CBM,CNKI,WANFANG and WEIPU.The search time was limited from the time of database builded to November 15,2020.After the literature was screened,the data was analyzed statistically.Part 2.Through Pubmed,CBM,CNKI,WANFANG and WEIPU,the clinical research of IS BSS related indicators was searched.The search time was from the time of database builded to May 1,2021.After the documents was strictly screened,the data was statistically analyzed.Part 3.Through the hospital case system,the basic patient information and test results were recorded by the researchers.EXCELL 2003 software was used to aggregate all the data obtained.On this basis,SPSS software was used to statistically analyze the differences in indicators between IS patients with blood stasis syndrome and non-blood stasis syndrome.Results.The first part included 886 literatures,involving 424 kinds of Traditional Chinese Medicine Compound Prescription,272 Chinese Medicine,442 1 medicine frequencies,of which 20 Chinese Medicine had a frequency greater than 65.Most of the Chinese Medicine used to prevent IS were activating blood and removing blood stasis,tonic medicines,and pacifying the liver and extinguishing wind.Most Chinese Medicine belong to the liver,spleen and heart meridian.They were mild and cold in nature,bitter and sweet in taste.The second part include 24 articles,which involving 9 indicators and 3 37 9 patients.The results of the network meta-analysis showed that Hcy are more significantly different[MD=0.930,95%CI(0.748,1.12),P<0.05],compared with the Hcy of normal people.Compared with the indicators of the Non-Blood Stasis Syndrome patients,Hcy was more significantly different[MD=0.212,95%CI(0.158,0.265),P<0.05].The third part of the study included 94 patients suffering from IS,of which 37 cases were in the Non-Blood Stasis Syndrome group,and 57 cases were in the Blood Stasis Syndrome group.Among the included test indicators,the normal indicators were:TC?LDL?Hcy?PT?TT?FG?APTT.The results of independent sample t test showed that Hcy was significantly different(P<0.05),and there were no difference in the others(P>0.05).Maan Whitney U rank sum test showed that significant differences in HB?PLA?ALB(P<0.05),but no difference in other indicators(P>0.05).The results of multiple differences showed that the levels of 7 indicators of TC?LDL?APTT?PT?TT?FG did not fluctuate much among different syndrome types.However,the fluctuations of Hcy?HB?PLA among different syndrome types were relatively large.Conclusion.1.Blood Stasis Syndrome was the main syndrome type of IS,which was closely related to the development of the disease.2.Hcy index could be used as a distinguishing indicator of IS and Blood Stasis Syndrome.But the specific judgment standard needs to be verified and measured by more rigorous and objective studies.