Effects Of Multimodal Analgesia On Fentanyl Dosage And Hemodynamics In Gynecological Laparoscopic Surgery

Objective:To investigate the effect of multimodal analgesia on the dosage of fentanyl and hemodynamics in gynecological laparoscopy by comparing the multimodal analgesic general anesthesia with the traditional model of analgesic general anesthesia.Methods:A total number of 100 patients from September to December 2016,who were admitted into Peking Union College Hospital for elective gynecological laparoscopic surgery.Among them,33 patients were infused with fentanyl,remifentanyl,non-steroidal anti-inflammatory drugs,and continuous intravenous injection of lidocaine.The other 67 patients were only infused with fentanyl.The levels of systolic blood pressure(SBP),diastolic blood pressure(DBP),mean arterial pressure(MAP)and heart rate(HR)were recorded when the patient enters the room(T0),immediately after inducing general anesthesia(T1),immediately when surgery began(T2),and immediately after surgery(T3),immediately after extubation(T4).The fentanyl dosage,preoperative and postoperative body temperature,operation time,anesthesia time,recovery time,hospital days and so on were also recorded.Results:Compared with group C,the dosage of fentanyl in M was significantly decreased(P<0.05),the levels of SBP and HR at T2 to T4,the MAP at T2 and T4,and the DBP at T4 in group M were significantly decreased(P<0.05).Compared with T0,SBP,DBP and MAP at T1 were significantly decreased in group M(P<0.05),then there was no difference.In group C,compared with T0,the SBP,DBP and MAP at T1 were significantly decreased(P<0.05),the SBP and MBP at T2 and T4,the DBP at T3 and HR at T2 to T4 were significantly increased(P<0.05).Conclusion:Multimodal analgesia is helpful to reducing intraoperative fentanyl consumption and maintaining hemodynamic stability.