| Objective Aging can lead to the decline of inhibitory control ability,and the brain mechanism of this decline is still controversial.Therefore,this study explored the influence of aging on inhibitory control ability and the characteristics of brain activity.(1)From the aspect of event-related f MRI,the differences of inhibitory control function between the elderly and young people,as well as the differences of brain activation characteristics in the task were compared,and the correlation between brain activation and inhibitory control ability was analyzed.(2)From the aspect of resting-state f MRI,we compared the resting-state brain activity characteristics of the elderly and young people,removed the influence of inhibitory control task,and further investigated the brain functional activity characteristics related to aging.Methods The study was divided into two parts: event-related f MRI and restingstate f MRI.Using the discovery MR750 3.0T magnetic resonance imaging system of General Electric Company of the United States,the brain activity data and behavior data of the elderly and young people were collected respectively under the inhibition control task and resting state.DPASF and SPSS were used to analyze the data.Result The response time of the elderly group was significantly higher than that of the young group(p< 0.001).The results of task state showed that the activation levels of right lingual gyrus,left lingual gyrus,left auxiliary motor area and left fusiform gyrus in the elderly group were significantly higher than those in the young group during the whole inhibitory control task;compared with the consistent condition,the brain activation of inconsistent condition in the right superior frontal gyrus and right middle frontal gyrus were higher,and the activation levels of the elderly group were significantly higher than those in the young group,and the activation levels of the right middle frontal gyrus were higher There is a significant correlation between the activation and the outcome of behavior.(2)The resting state results showed that compared with the young group,the fractional amplitude of low-frequency fluctuation of occipital lobe increased,the frontal lobe decreased,and the regional homogeneity of cerebellum decreased in the old group,which was significantly correlated with the reaction time under the condition of inconsistent inhibitory control.The results of resting state functional connectivity showed that the functional connectivity of right superior frontal gyrus and left middle temporal gyrus,left middle frontal gyrus and right insula,left middle frontal gyrus and left middle temporal gyrus in the elderly group were stronger than those in the young group.Conclusion(1)The functional changes of brain regions related to inhibitory control in the elderly are related to the decreased performance of inhibitory control task.(2)The decline of inhibitory control function with age is mainly related to the changes of function and functional connectivity of occipital lobe,frontal lobe and cerebellum. |
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