| BackgroundPost-stroke depression generally occurs after stroke and can be manifested as low mood,loss of interest,etc.,which has adverse effects on patients and their families.The commonly used method for the prevention of post-stroke depression is drug prevention,but its early application is limited due to its adverse reactions.ObjectiveIn this research,to observe the preventive effect of hydrogen on PSD in patients with acute cerebral infarction by giving hydrogen inhalation to patients with acute cerebral infarction and discuss its possible effect from the perspective of oxidative stress.MethodA total of 87 patients with acute cerebral infarction who were hospitalized in the department of neurology of the First Affiliated Hospital of Xinxiang Medical University from June 2020 to April 2021 were selected.Using random number table method,the enrolled patients will be randomly assigned to hydrogen inhalation group（n=43）and control group（n=44）,according to general clinical data including gender,TOAST classification and thrombolysis situation.The control group was given routine neurological treatment.The hydrogen inhalation group was given hydrogen inhalation through a nasal tip on the basis of the conventional treatment of the control group.The hydrogen concentration is about 3%and the flow rate was 500ml/min.The hydrogen inhalation group was given hydrogen inhalation for 7 days,twice a day,interval 6～8 hours,each time for 1 hour.The changes of HAMD-17 score,PSD incidence and MMSE score before hospitalization and at 1,3,and 6months after treatment were compared between the two groups.The changes of PSQI scores before hospitalization and the first month after treatment were compared between the two groups.The changes of serum MDA,SOD levels before hospitalization and within a specified time after treatment were compared between the two groups.Result1.Comparison of clinical baseline data between the two groups:Baseline data of patients between two groups were balanced such as age,gender,TOAST classification,thrombolysis status,education level,indicating that the two groups were not significantly different（P>0.05）.2.Depression score before and after treatment in the two groups:Before treatment,comparing HAMD-17 score of hydrogen inhalation group and control group,the difference doesn’t exist（P>0.05）;at the 1st,3rd,and 6th month after treatment,the HAMD-17 scores of the control group were higher than those before treatment,and after treatment,the HAMD-17 scores of the hydrogen inhalation group were lower than those of the control group at the same period,and the difference exists（P<0.05）.3.The incidence of PSD before and after treatment in the two groups:Before treatment,the incidence of PSD in both groups was 0;at the 1st,3rd,and 6th month after treatment,comparing the control group,the incidence of PSD in the hydrogen inhalation group was lower,and the difference exists（P<0.05）.4.Serum MDA and SOD levels of hydrogen inhalation group and control group before and after treatment:Before treatment,the difference doesn’t exist in serum MDA and SOD levels between the two groups（P>0.05）;before treatment and after treatment,comparing serum MDA and SOD levels of the two groups of patients,MDA increased,SOD decreased,the difference exists（P<0.05）;comparison of serum MDA and SOD levels in the two groups after treatment,the former difference doesn’t exist（P>0.05）,the latter the difference exists（P<0.05）.5.Cognitive function scores before and after treatment in the two groups:Before treatment,comparing MMSE score of hydrogen inhalation group and control group,the difference doesn’t exist（P>0.05）;at the 1st,3rd,and 6th month after treatment,there was no significant change in the MMSE scores between the two groups compared with before treatment.After treatment,there was no significant change in the MMSE score between two groups in the same period,and the difference doesn’t exist（P>0.05）.6.Sleep status of the two groups before and after treatment:Before treatment,comparing PSQI score of hydrogen inhalation group and control group,the difference doesn’t exist（P>0.05）;in 1st month after treatment,the PSQI scores of the two groups were lower than those before treatment,and the difference exists（P<0.05）;after treatment,the PSQI score of the hydrogen inhalation group was lower than that of the control group in the same period,and the difference exists（P<0.05）.7.During hospitalization,the total incidence of adverse events in the hydrogen inhalation group was 27.91%,and that in the control group was 25.00%.ConclusionHydrogen inhalation can improve post-stroke depression and sleep quality in patients with acute cerebral infarction,and its effect is related to regulating the level of oxidative stress in ischemic brain tissue area. |
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