The Value Of PCT Combined With ESOFA Score In Prediction Of Prognoses Of Patients With Sepsis

Objective:To investigate the value of procalcitonin（PCT）combined with electronic sequential organ failure assessment（e SOFA）in prediction of prognoses of patients with sepsis,and provide more data support for the application of e SOFA in intensive care unit.Methods:The clinical data of 107 patients with sepsis in the intensive care unit of Lu’an people’s Hospital from November 2017 to November 2021 were analyzed retrospectively.The patients were divided into the death group（n=32）and the survival group（n=75）according to the 28 d of treatment outcomes.The PCT level,e SOFA score,sequential organ failure assessment（SOFA）score and related data were collected,and the risk factors of 28 d mortality in patients with sepsis were analyzed by the multivariate logistic regression.The receiver operating characteristic curve（ROC）was used to evaluate the predictive value of PCT level,e SOFA score,SOFA score and PCT combined with e SOFA score in patients with sepsis.Result:The results of 28 d treatment showed that the serum PCT level and e SOFA score in death group were higher than those in survival group,{PCT ng/m L: 23（17.23,25.62）vs10.8（8.73,13）,P<0.001;e SOFA score: 4.5（4,5）vs 3（2,3）,P<0.001}.Multivariate Logistic analysis was performed with age（<65 years old,≥65 years old）,septic shock,AKI,Lac,PCT,APACHEⅡ score,SOFA score,e SOFA score as independent variables and survival and death as dependent variables.The results showed that PCT（OR1.545,95%CI 1.211～1.971;P<0.001）and e SOFA score（OR 1.976,95%CI 1.169～3.921;P=0.029）were independent risk factors for 28 d mortality in patients with sepsis.The area under the receiver operating characteristic curve（ROC）analysis showed that the AUC of PCT and e SOFA score in predicting 28 d mortality of sepsis patients were0.856（95%CI 0.767～0.944;P<0.001）and 0.863（95%CI 0.783～0.943;P<0.001）.When PCT combined with e SOFA score was to predict sepsis patients,the AUC was0.928（95%CI 0.861～0.969;P<0.001）,sensitivity and specificity were 87.5% and 88.0%respectively.Conclusion:PCT level and e SOFA score were higher in sepsis death group than in survival group.Both PCT level and e SOFA score were independent risk factors for the 28 d mortality in patients with sepsis,suggesting that they were closely related to the mortality of patients with sepsis.The combination of PCT level and e SOFA score could improve the predictive efficacy of patients with sepsis,and it is better than single index detection.