| Objective The specific metabolic activities of intestinal flora not only maintain the micro ecological balance of intestinal microecology systems but also play a vital role in maintaining human health.The immunity of the elderly decreased gradually with age.The barrier of the intestinal mucosa of the elderly population is weakened and the ability to resist the invasion of harmful substances and pathogenic microorganisms from the outside is reduced due to years of poor dietary habits and hypofunctions of gastrointestinal system,In addition,the ecological stability of intestinal microbiota is much lower than that of the young population with the decrease of the proportion of beneficial and harmful bacteria.Heart failure is one of the greatest challenges of maintaining cardiovascular health in the elderly which often accompanied with pneumonia,and the intestinal flora of these patients is more likely to be interfered by drugs or other factors.The third-generation cephalosporins are commonly used for anti-infection therapy in elderly patients with heart failure accompanied with pneumonia due to their strong tissue penetration,less side effects and high safety,However,antibiotics tend to affect the normal intestinal flora while killing harmful bacteria,resulting in a decrease,an imbalance or even an inversion in the number and the kind of intestinal flora,which will lead to a series of gastrointestinal symptoms such as abdominal pain and diarrhea.If we don’t intervene,long-term dysbacteriosis may cause other systemic diseases,which even affect the prognosis of elderly patients.There are few studies on the effects of the third-generation cephalosporins on intestinal microbiota at present,but in recent years the quality of life of the elderly is riding a wave of renewed public interest,and the intestinal flora of the elderly is attracting increased attention.This study aims to investigate the effects of the short-term use of the third-generation cephalosporins on gut microbiota in elderly heart failure patients accompanied with pneumonia.Methods A total of 7 cases of elderly heart failure patients accompanied with pneumonia were enrolled in this study from December 2020 to May 2021 in Hospital.The stool specimens were collected before the use of the third-generation cephalosporins,3 days after the use and 5 days after the use,respectively,16 S r RNA sequencing was adopted to analyze the changes of the gut microbiota.Results There was no statistical significance in the diversity（Shannon index,Faith-PD index,Chao1 index）and the number of intestinal flora in the elderly heart failure patients accompanied with pulmonary infection treated with the third-generation cephalosporins on day 3（P >0.05）.5 days after the use of the third-generation cephalosporins,the diversity of intestinal flora（Shannon index,Chao1 index,Faith-PD index）in the elderly heart failure patients accompanied with pneumonia was decreased than before the use of the third-generation cephalosporins（P<0.05）.Meanwhile,the structure of intestinal flora changed at phylum,family and genus levels and the abundance of Bacteroidetes,Bacteroidi a,Lachnoclostridium,Roseburia,Eubacterium coprostanoligenes,Ruminococcaceae＿UCG-002,Ruminococcaceae＿UCG-005 decreased（P<0.05）.Conclusions In this study,the intestinal microflora of elderly patients with heart failure accompanied with pneumonia using the third-generation cephalosporins were detected dynamically in a short time,and it was found that the diversity of intestinal flora in the elderly heart failure patients accompanied with pneumonia who were treated with the third-generation cephalosporins decreased,and the beneficial bacteria that produce short chain fatty acids decreased as well.All of these provide a data foundation for the further researches on the effects of antibiotics on gut bacteria in elderly Heart Failure Patients Accompanied with Pneumonia,at the same time it is helpful to guide the rational application of the third-generation cephalosporins. |
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