Clinicopathological Analysis Of 1489 Cases Of Intracranial Meningioma In A Single Center

Objective: To study the characteristics of intracranial distribution of meningiomas.The relationship between the diameter of meningioma,WHO grade of meningioma and patient’s gender,immunohistochemical staining results of meningioma.Methods: The pathological data,related medical history and imaging data of 1489 patients with meningioma treated by surgery were retrospectively analyzed.SPSS 26.0 software was used for statistical analysis.The basic clinical data of meningioma patients,the gender distribution and pathological type distribution of each age group,and the distribution of pathological types of various parts were used descriptive statistics method;the average age of different genders was compared by T test,and age was measured by （?）±S description.The number of WHO Ⅲ cases is relatively small,so the WHO classification is divided into WHOⅠ group and WHO Ⅱ-Ⅲ group in statistics.The relationship between Ki-67 and WHO grade was analyzed by Mann-Whitney U test and ROC curve analysis.The relationship between tumor size,gender,and immunohistochemical staining results was measured by Mann-Whitney U test.The relationship between WHO grade,gender,and immunohistochemical staining results was tested by chi-square test.Binary logistic regression was used for multivariate analysis of WHO grading of meningiomas,and P<0.05 was considered statistically significant.Results: The 1489 patients with meningioma were mainly concentrated in 20-79 years old,the average age of the patients was（54.43±10.429）years old,and the male to female ratio was 1:2.96.The main pathological types of meningiomas were transitional type,accounting for 37.41%;followed by fibrous type,accounting for 20.48%;followed by epithelial type,accounting for 18.33%.The main site of meningiomas was supratentorial convexity,accounting for 47.6%;the average diameter was（3.53±1.84）cm.The overall diameter distribution of meningiomas in male patients was larger than that in female patients,the overall diameter distribution of meningiomas in Ki-67＜5% was larger than that in Ki-67<5%,and the overall diameter distribution of GFAP-positive meningiomas Greater than the overall diameter distribution of GFAP-negative meningiomas.The overall diameter distribution of S-100-negative meningiomas was larger than that of S-100-positive meningiomas,and the overall diameter distribution of CK-pan meningiomas was larger than that of CK-panpositive meningiomas.The immunohistochemical staining results of PR,EMA,CD34,Vimentin,SSTR2,STAT6,H3K27me3 and the size of meningioma were not statistically significant.Men have a greater chance of developing WHO Ⅱ-Ⅲ meningiomas than women.The positive rates of CD34,GFAP,STAT6,and CK-pan in meningiomas were all low,and there was no significant difference in the positive rates between WHOⅠand WHO Ⅱ-Ⅲ meningiomas.The positive rates of EMA,vimentin,SSTR2,and H3K27Me3 were all higher in meningiomas,but there was no significant difference in the positive rates between WHOⅠand WHO Ⅱ-Ⅲ meningiomas.PR was more positive in WHO grade I meningiomas than in WHO grade Ⅱ-Ⅲ meningiomas.Ki-67<5% can be used as the cutoff value for WHO gradeⅠand Ⅱ-Ⅲ meningiomas.Conclusion: 1.Summarize the data of 1489 patients with meningioma.The gender composition ratio,the average age of onset,the proportion of each pathological type,and the order of onset sites may have changed in the past 20 years.2.Gender,Ki-67 level,GFAP,S-100,CK-pan and size of meningioma were closely related.3.PR,EMA,CD34,Vimentin,SSTR2,STAT6,H3K27me3 and other immunohistochemical staining results have no relationship with the size of meningioma.4.Men have a greater chance of developing WHO Ⅱ-Ⅲ meningiomas than women.5.The expressions of CD34,GFAP,STAT6 and CK-pan were all lower in meningioma,and there was no difference between WHOI grade and WHO Ⅱ-Ⅲ grade meningioma.6.The expression of EMA,vimentin,SSTR2,H3K27Me3 was higher in meningioma,but there was no difference between WHO grade I and WHO Ⅱ-Ⅲ meningioma.7.The expression of PR is different in WHOⅠgrade meningioma than WHO Ⅱ-Ⅲ grade meningioma,and higher in WHOI grade.It is of great help in the diagnosis of meningioma.8.Ki-67<5% can be used as the cutoff value for WHOⅠand Ⅱ-Ⅲ meningiomas.9.When female patients suffer from gynecological tumors or thyroid tumors,regular head MRI examinations can help early detection of meningiomas.