| Objective:To figure out the preoperative sensitive prognostic index of transarterial chemoembolizatio(TACE),this study analyzed the correlation between preoperative ANRI(aspartate aminotransferase to neutrophils ratio)and postoperative survival of hepatocellular carcinoma(HCC)patients with TACE,and explored the evaluation the prognosis value of preoperative ANRI for TACE patients.Methods:Through the collection of patients with hepatocellular carcinoma who underwent TACE treatment in the Interventional Department of our hospital from January 2009 to December 2014.A total of 301 HCC patients who received TACE treatment were included in this study,collect patients’ general clinical data,laboratory results and imaging data through the electronic medical record system.The clinical data of all subjects were retrospectively analysis and comparison of the preoperative ANRI,NLR(neutrophil-lymphocytes ratio)and general clinical factors were the single factor analysis of multiple factors,and draw the receiver operating characteristic curve(ROC curve),all cases can be divided into: ANRI≤7.9 group and ANRI > 7.9 group,through mapping Kaplan Meier survival curve analysis ANRI for progression-free survival(PFS).The predictive value of Overall survival(OS)and postoperative survival assessment for different hepatocellular carcinoma subgroups.Results:Preoperative ANRI level and hepatitis B viral hepatitis(P=0.002),the combined liver cirrhosis(P=0.001),tumor lesion diameter(P=0.002),with PVTT(P=0.042)and Child score(P=0.002)five clinical factors exist significant correlation(P<0.05).Through the single factor and multiple factors analysis results,that study suggested that preoperative ANRI tumor,lesion diameter,and PVTT were independent influencing factors of postoperative PFS and OS(P < 0.05).The OS of patients in ANRI≤7.9 group was significantly better than those in ANRI>7.9 group(81.6%,61.4% and 56.3% VS 70.7%,39.2% and 31.7%,P<0.001)in 1,3,5 years after surgery,and the PFS of patients in ANRI≤7.9 group before the surgery was also significantly better than that in ANRI>7.9 group before the surgery(59.6%,46.8% and42.9% VS 40.7%,23.6% and 20.1%,p<0.001).For patients with stage Ⅰa-Ⅱa type,the postoperative OS(88.2%,75.1%,65.7% VS 76.9%,44%,36.9%,P<0.001)and PFS(69.4%,54.1%,50.6% VS 48.1%,27.5%,23.8%,P<0.001)of the preoperative ANRI≤7.9 group is better than that of preoperative ANRI > 7.9 group;For patients with lesions > 5 cm in diameter,the postoperative OS(72.6%,48.8%,43.2% VS58.3%,29.1%,22.3%,P=0.004)and PFS(47.2%,37.5%,26.7% VS35.2%,23.9%,12.4%,P = 0.002)of the preoperative ANRI≤7.9 group is better than that of preoperative ANRI>7.9 group;and for patients without portal vein tumor thrombosis,the postoperative OS(85.4%,67.1%,59.8% VS 75.6%,57.3%,44.6%,P<0.001)and PFS(64.8%,51.3%,47.1% VS 45.1%,27.5%,23.9%,P<0.001)of the preoperative ANRI≤7.9 group is also better than that of preoperative ANRI > 7.9group.Conclusions:1.Preoperative ANRI level is an independent risk factor for the prognosis of HCC patients with TACE,the prognosis of HCC patients with preoperative ANRI>7.9is poor after TACE;2.For patients with different liver cancer subgroups of stage Ia-IIa,tumor lesions greater than 5 cm in diameter,and no portal vein tumor thrombus,The prognosis of preoperative ANRI > 7.9 is poor. |
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