| Objective:In this study,serum levels of 25-OH-D3 and serum total IgE were detected in patients with allergic rhinitis and asthma syndrome and children with children’s health insurance examination in the outpatient department,so as to explore the correlation between serum levels of the patients with allergic rhinitis and asthma syndrome and children with children’s health insurance examination,and to compare and analyze the changes of vitamin D levels in the blood of patients with allergic rhinitis and asthma syndrome before and after treatment,then by evaluating the condition of patients with allergic rhinitis and asthma syndrome recovery,and patients with allergic rhinitis and asthma syndrome in children with vitamin D at a lower level,the content of 25-OH-D3 recovered 3 months after symptom control,for disease prevention and treatment of allergic rhinitis and asthma syndrome can provide strong evidence by controlling the vitamin D levels.Methods:From September 2017 to September 2018,a total of 86 cases of hospitalized children in the pediatric ward of the affiliated hospital of Taishan medical college and healthy children in the outpatient department of the children’s health insurance department were selected,including 43 cases in the allergic rhinitis and asthma syndrome group and 43 cases in the children’s health insurance and physical examination group.1.The level of 25-OH-D3 was determined by elisa,and the content of total IgE in serum was determined by radioimmunoassay.2.The children in the allergic rhiniti-asthma syndrome group were given normal treatment such as anti-inflammatory,antiasthmatic and antispasmodic,and the level of25-OH-D3 was measured again 3 months later,so as to study the correlation between the content of 25-OH-D3 in the patients with allergic rhiniti-asthma syndrome in the acute stage and the content of 25-OH-D3 after the condition stabilized.By comparing the degree of changes in 25-OH-D3 level in patients with syndrome after antiphlogistic,antiasthmatic and relief of respiratory tract spasm,the significance can be determined.SPSS20.0 statistical software was used to calculate the mean standard deviation for the data in the experiment.Chi-square test was used for gender composition comparison.Pearson correlation method was used for correlation analysis of the two factors.Results:Analysis from the age: the average age of the allergic rhinitis and asthma syndrome group was 70.92 months,and the average age of the healthy children group was 65.16 months,P = 0.31.BMI analysis: the average BMI of the allergic rhinitis and asthma syndrome group was 16.41,and that of the control group was 15.94,P = 0.15.Analysis of the content of 25-OH-D3 in serum: the 25-OH-D3 in the case group was 16.672.47ng/ml,and the level of 25-OH-D3 in the children’s health insurance group was25.44 3.19 ng/m,P < 0.05,indicating that the level of 25-oh-d3 in the group with allergic rhinitis and asthma syndrome was lower than that in the control group.Total IgE level was 201.72 102.51IU/ml in the case group and 88.67 22.31IU/ml in the control group,P< 0.05.Relationship between serum 25-OH-D3 and total IgE level: the higher serum25-oh-d3 level was,the lower total IgE content was,presenting a negative correlation(r=-8.12,P < 0.05).Comparison of vitamin D3 level between the allergic rhinitis and asthma syndrome group 3 months after treatment and before treatment: the level of25-OH-D3 before treatment was lower than that after treatment,P < 0.05.Conclusions:The blood level of 25-OH-D3 in healthy children is higher than that in children with allergic rhinitis and asthma syndrome.The level of total IgE in serum and the content of25-OH-D3 in serum are negatively regulated,so it is speculated that total IgE is inhibited by 25-OH-D3,so as to prevent and treat allergic rhinitis and asthma syndrome.A new adjuvant therapy for allergic rhinitis and asthma syndrome--vitamin D supplementation may be applied in clinical practice.The vitamin D3 level of children with allergic rhinitis-asthma syndrome was significantly higher than that of children with acute episode after3 months of standardized and rational administration of anti-inflammation and antiasthma. |
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