Clinical Observation Of Yueju Pill Combined With Banxia Houpu Decoction Combined With Western Medicine In The Treatment Of Spittoon-gas Obstruction Reflux Esophagitis With Depression

Objective:To observe the clinical symptom efficacy,gastroscopic efficacy,long-term efficacy,long-term efficacy and adverse reactions of Yueju Pill and Banxia Houpu Decoction combined with Western medicine in the treatment of qi stagnation and phlegm-blocking reflux esophagitis with depression,To provide ideas for clinical treatment of related diseases.Methods:1.Choose between November 2019 and June 2021 in the hubei province combine traditional Chinese and western medicine hospital the inpatient and outpatient service were included in the standard of digestive diseases,76 cases of qi depression phlegm obstruction in patients with reflux esophagitis with depression as the research object,according to the random number table method,they were divided into observation group of integrated Traditional Chinese and Western medicine and control group of western medicine,38 cases in each group.2.Control group was treated with esomeprazole enteric-coated tablet combined with Desixin（flupentixol melitracine tablet）;Observation group was additionally treated with Yueju Pill and Banxia Xiexin Decoction on the basis of control group.The treatment course of both groups was 8 weeks.3.General clinical data such as gender,age and course of disease were collected.TCM symptom score,RDQ scale score,HAMD scale score and esophageal mucosal repair under gastroscope were used as efficacy evaluation indexes.The TCM symptom score,RDQ rating scale,HAMD rating scale and adverse reactions after treatment were observed and compared before and after treatment,and the data were recorded.Results:1.Comparison of clinical data:there were no statistically significant differences in gender composition,age distribution and disease course distribution between the two groups（P>0.05）,with comparability.2.RDQ score:RDQ score of 2 groups before treatment showed no significant difference（P>0.05）;RDQ score of both groups improved after 8 weeks of treatment compared with before treatment（P<0.01）,and the observation group was better than the control group in improving RDQ score（P<0.05）.3.Comparison of the scores of TCM syndromes（throat discomfort,such as phlegm stalk and chest discomfort）:After 8 weeks of treatment,TCM main symptom scores in both groups were significantly improved compared with before treatment（P<0.01）,and the advantage of the observation group in improving throat discomfort symptoms was especially obvious compared with the control group（P<0.01）,the difference was statistically significant;The two groups were equally effective in improving chest discomfort symptoms（P>0.05）,and there was no statistical significance.4.Comparison of TCM symptom scores and TCM syndrome efficacy:there was no significant difference in TCM symptom scores between the two groups before treatment（P>0.05）,after 8 weeks of treatment,the total score of TCM symptoms in both groups decreased compared with before treatment（P<0.01）,and the decrease degree of score in the observation group was significantly greater than that in the control group（P<0.01）.After treatment,the total effective rate was 77.77%in the control group and 94.29%in the observation group,which was higher than that in the control group（P<0.05）.5.Comparison of HAMD scores:After 8 weeks of treatment,HAMD scores were compared between the two groups,HAMD scores in both groups improved significantly compared with before treatment（P<0.05）,and the decrease degree of the observation group was significantly better than that of the control group（P<0.05）.6.Comparison of endoscopic manifestations:After 8 weeks of treatment,endoscopic manifestations in both groups were significantly improved compared with before treatment（P<0.05）,and there was no significant difference between the two groups（P>0.05）,indicating that the two groups had similar efficacy in promoting esophageal mucosal repair.7.Comparison of adverse reactions:After 8 weeks of treatment,the incidence of adverse reactions was 30.56%in the control group and 14.29%in the observation group,and P<0.05 is comparable.8.Comparison of long-term efficacy:RDQ score of the treatment group and the control group was higher than RDQ score of the treatment group after 8 weeks of treatment for half a year,However,the RDQ score in the observation group was significantly lower than that in the control group（P<0.01）,It shows that the long-term effect of RE with depression in observation group is better than that in control group.9.Correlation between the difference between the total score of TCM symptoms and the change of depression score between the two groups before and after treatment:there was a positive correlation between the two groups（correlation coefficient R=0.327）,and the correlation was statistically significant（P<0.05）.Conclusion:1.Yueju Pill combined with Banxia Houpu Decoction combined with Western medicine can effectively improve the symptoms and endoscopic performance of patients with qi-stagnation and phlegm-blocking reflux esophagitis accompanied by depression,and the therapeutic effect is better than western medicine alone,with relatively positive safety and efficacy.2.Yueju Pill combined with Banxia Houpu Decoction combined with Deanixin has lower adverse reaction rate and better long-term efficacy.3.The greater the difference in the total score of TCM symptoms,the greater the change in the depression score of patients with RE combined with depression.