Iron Metabolism And Its Influencing Factors In Hematologic Malignancy And Its Effect On Quality Of Life

Objectives 1 To investigate the incidence of absolute iron deficiency and functional iron deficiency in patients with hematological malignancies.2 To investigate the influence of inflammatory cytokines on iron deficiency in patients with newly diagnosed hematological malignancies.3 To explore the effect of various extents of iron deficiency on patients’ physical fitness and quality of life.Methods From November 2019 to July 2020,102 newly diagnosed hematological malignancies in the Affiliated Hospital of North China University of science and technology were collected as the research objects.Among them,43 patients with TSAT<50% and SF≤800ng/m L were grouped as iron deficiency;59 patients with SF>800ng/m L or TSAT≥50% were grouped as iron saturation.The age,gender,body mass index,diet,nutritional status,disease type and other general conditions of the patients were investigated;iron metabolism parameters such as Si,SF,hepcidin and inflammatory factors such as IL-6 and IL-1 were detected;the FACT scale score was chosen to evaluate of all patients before treatment.All data were collected and a database was established.The measurement data matching the normal distribution were expressed as "mean standard deviation",and the comparison was performed by t-test;the measurement data not matching the normal distribution were expressed as "median",and the comparison was performed by kruskai Wallis test.Multivariate logistic regression analysis was used to assess the influencing factors of iron metabolism.When a P<0.05,the difference was considered as statistical significance.Results 1 Among 102 patients with hematological malignancies,59(57.8%)showed iron saturation and 43(42.2%)showed iron deficiency.Among the patients with iron deficiency,90.7%(39/43)were with functional iron deficiency(FID).2 There was no significant difference in age,gender,disease type and hemoglobin(HB)between iron deficiency group and iron saturation group(P>0.05);the median of Si,TF and TSAT% in iron deficiency group was lower than that in iron saturation group,and the difference was statistically significant(P<0.05).There was no significant difference in SF between the two groups(P>0.05).The median levels of hepcidin,IL-6 and TNF-α in iron deficiency group were higher than those in iron saturation group;the median of EPO in iron deficiency group was lower than that in iron saturation group(P<0.05),but there was no significant differences in IL-1 and IFN-γ between the two groups(P>0.05).The results showed that IL-6 and hepcidin were the influencing factors of iron deficiency in patients with hematological malignancies(P<0.05).3 There was no significant difference in FACT score between the two groups(P>0.05).Conclusions 1 Functional iron deficiency(FID)is the most common iron metabolic state in patients with newly diagnosed hematologic malignancies.2 The levels of EPO,Si and TSAT% in peripheral blood of patients with iron deficiency were lower than those of patients with iron saturation.The expression levels of TF,hepcidin,IL-6 and TNF-α in peripheral blood of patients with iron deficiency were higher than those of patients with iron saturation.3 The serum levels of IL-6 and hepcidin may be the independent risk factors of iron deficiency in patients with newly diagnosed hematological malignancies.4Iron metabolism has no direct effect on the quality of life.Figure 0;Table 6;Reference 121...