Correlation Between Red Cell Distribution Width-to-platelet Ratio In Patients With Type 2 Diabetesmellitus And Nonalcoholic Fatty Liver Disease

Objective: Study the changes of red blood cell distribution width and platelet ratio in peripheral blood of patients with type 2 diabetes and non-alcoholic fatty liver disease.Methods: A total of 375 case data were collected from hospitalized patients in the Department of Endocrinology from January 2019 to August 2020 and the normal population who received physical examination at the physical examination center during the same period.According to the results of liver color Doppler ultrasound examination,375 subjects were divided into 4 groups,T2 DM with NAFLD group(1 group)152 cases,simple T2 DM group(2 groups)102 cases,simple NAFLD group(3 groups)62 cases,healthy control group(4 groups)59 cases.Collect clinical data of patients,test blood routine,fasting blood glucose,fasting C-peptide,fasting insulin,glycosylated hemoglobin,liver function,kidney function,blood lipids,calculate red blood cell distribution width and platelet ratio,body mass index,compare between groups based on data Analysis of variance,rank sum test,and χ2 test were used for data characteristics,binary logistic regression analysis was used to analyze the risk factors of T2 DM with NAFLD,the correlation between RPR and various indicators was analyzed by Pearson,and the predictive value of RPR in the diagnosis of T2 DM with NAFLD was used by ROC curve.Results: 1.The differences in gender,BMI,RDW,PLT,RPR,FBG,ALT,AST,GGT,ALB,DBIL,TC,TG,HDL-C,BUN,CR among the four groups were statistically significant(P<0.05).And the median RPR of group 1 was 0.070(0.062,0.080)>the median of group 2 was 0.060(0.050,0.063)>the median of group 4 was 0.057(0.049,0.060).The median RPR in group 1 was 0.070(0.062,0.080)> the median in group 3was 0.061(0.055,0.067)> the median in group 4 was 0.057(0.049,0.060).2.The difference in FINS and FCP between the T2 DM with NAFLD group and the T2 DM group alone was statistically significant(P<0.05).3.RPR has a significant positive correlation with FBG,ALT,AST,IBIL,TG,TC,LDL-C,and a significant negative correlation with HDL-C(P<0.05).4.The risk factors for NAFLD in T2 DM patients were age,BMI,FCP,RDW,RPR,ALT,AST,GGT,TG(P<0.05).PLT and HDL-C are the protective factors of NAFLD in T2 DM patients(P<0.05).5.The ROC curve shows that the maximum area under the RPR score curve(AUC)is 0.856,the sensitivity is 53.33%,and the specificity is 98.00%;the maximum area under the RDW score curve(AUC)is0.615,the sensitivity is 91.4%,and the specificity is 31.4%.Conclusion: RPR levels in normal healthy people,patients with T2 DM and NAFLD alone,and T2 DM with NAFLD are sequentially increased.It is closely related to T2 DM and NAFLD.RPR is a risk factor for NAFLD in patients with T2 DM.The treatment provides new insights.