Single Center Study Of Vascular Closure Devices In Transarterial Chemoembolization

Objective: To explore the efficacy and safety of using vascular closure device(VCD)in the femoral artery puncture approach in transarterial chemoembolization(TACE).Method: Clinical data of patients who underwent TACE and used VCD or manual compression(MC)for hemostasis in our hospital from January 2020 to September2020 were retrospectively collected.A total of 94 patients were included in this study.Patients were divided into VCD group and MC group according to different hemostasis methods,including 31 cases in VCD group and 63 cases in MC group.Preoperative color Doppler flow imaging(CDFI)was used in all patients to evaluate the possibility of using VCD to puncture the femoral artery.Preoperative complete blood count index,Liver function tests index,renal function tests index and coagulation index were recorded.Hemostasis methods,time to hemostasis(TTH),time to ambulation(TTA),success rate of hemostasis and complications were recorded.Intergroup comparisons were performed using a Group t test,chi-square test or Fisher’s exact test to analysis the efficacy and safety of VCD.Result:1.A total of 94 patients were included in this study,and baseline data and intraoperative and postoperative data are complete.2.All patients were successfully treated with TACE,including 31 cases with VCD and 63 cases with MC.The baseline characteristics of two groups were similar.3.The success rate of hemostasis in the VCD group was 90.3% versus 85.7% in the MC group(P>0.05).4.The mean time to ambulation(4.1±0.6 versus 9.5±2.1h)after operation was shorter in VCD group compare to MC group(p<0.001).5.No sever complications were found in both groups.Postoperative oozing of blood at the puncture site consisted of 3 in the VCD group and 9 cases in the MC group.Conclusion:Compared with MC,VCD can effectively reduce TTA,improve patient comfort and reduce the negative effects caused by long-time ambulation.