Clinical Characteristics And Related Factors Of Vascular Calcification In Dialysis And Non-dialysis End Stage Renal Disease Patients

Objective: To assess the differences about the situation and related factors of vascular calcification(VC)in patients with dialysis and non-dialysis end stage renal disease(ESRD)patients.Methods: This study enrolled the end stage renal disease patients at stable status and treated in Cangzhou Central Hospital.The patients were divided into calcified group and non-calcified group according to the presence or absence of Abdominal aortic calcification(AAC).Clinical characteristics,related factors and the differences about vascular calcification between dialysis patients and non-dialysis ESRD patients were analyzed.Results: A total of 191 patients were enrolled in this study.The incidence of AAC in dialysis group was higher than that in non-dialysis patients(P<0.05).AAC score was significantly lower in non-dialysis patients than in dialysis patients(P<0.05).In dialysis patients,the risk of severe calcification was higher than that of dialysis patients(P<0.05),after comparing two groups of patients(with or without calcification)in all the patients,significant differences can be found in different aspects.These included patient’s age,dialysis,the percentage of having diabetes,creatinine,high-density lipoprotein,blood glucose,uric acid,homocysteine,serum calcium,phosphorus and calcium-phosphorus product.According to the Logistic regression analysis,it was shown that age(OR=1.083,95% CI 1.052～1.114,P<0.001)were independent risk factors for AAC.Among non-dialysis patients,there are significant differences in age,diabetes,high-density lipoprotein,blood glucose,serum calcium and phosphorus.Age(OR=1.072,95% CI 1.034～1.111,P<0.001)and blood glucose(OR=1.278,95% CI 1.045～1.563,P=0.017)were independent risk factors for AAC.Among dialysis patients,there are significant differences in age,hypertension,creatinine,uric acid.Age(OR=1.084,95% CI 1.033～1.139,P<0.001)and hypertension(OR=5.179,95% CI 0.927～28.923,P=0.036)were independent risk factors for AAC.Conclusions: Clinical characteristics and risk factors of VC were different between dialysis patients and non-dialysis end stage renal disease patients.Therefore,individua Iized and optimal management is necessary for dialysis and non-dialysis end stage renal disease patients.