Analysis Of Expression And Clinical Characteristics Of Multiple Driver Genes In Non-small Cell Lung Cancer

Objective:To analyze the expression of multiple driver genes in non-small Cell Lung Cancer(NSCLC)and their corresponding clinical characteristics,and to provide a scientific theoretical basis for screening the target population for molecular targeted therapy of multiple driver genes in non-small Cell Lung Cancer(NSCLC),and to provide a reference for optimizing targeted therapy in patients with NSCLC.Methods:Retrospective analysis method is used to collect the second hospital,hebei medical university on January 1,2019-December 31,2021 by the pathology diagnosis of non-small cell lung cancer and line drive gene detects lung cancer patient records,a total of 212 patients,Clinical data of these patients were collected,including gender,age,smoking history,histological type and TNM stage of lung cancer,SPSS 26.0 software was used for statistical analysis of the collected data to summarize the mutation rate of driver genes in patients with NSCLC and the corresponding clinical characteristics.Results: 1.The mutation rate of EGFR,KRAS,ALK,BRAF,MET,HER-2,ROS1,RET,PIK3 CA gene in NSCLC patients was 41.1%,9.4%,8.5%,6.1%,1.9%,1.9%,1.9%,0.9%,1.4%,respectively.EGFR,ROS1 and PIK3 CA gene mutations were combined with their own or other gene mutations.2.EGFR gene mutations were mainly in exon 21 and 19,mainly in female patients with lung adenocarcinoma without smoking history,and the difference was statistically significant after statistical analysis.KRAS mutations occurred mainly in other types of NSCLC(adenosquamous carcinoma or sarcomatoid carcinoma).PIK3 CA mutations occurred mainly in squamous cell carcinoma patients,followed by adenocarcinoma patients.ALK mutations occur mainly in lung cancer patients under 60 years of age;MET mutations occur mainly in women with lung cancer;No statistically significant clinical features were found for BRAF mutation,HER-2 mutation,ROS1 mutation and RET mutation.Conclusions:1.Mutations in NSCLC may exist alone or co-exist.2.EGFR,KRAS,ALK and BRAF gene mutation rate was relatively high in NSCLC,while ROS1,HER-2,RET,MET and PIK3 CA gene mutation rate was relatively low.