Analysis Of Imaging And Electrophysiological Characteristics Of Optic Nerve Damage In Patients With Neuromyelitis Optica Spectrum Disease With AQP4 And MOG Antibody Positive

Background Neuromyelitis optica(NMO)mainly affects the optic nerve and spinal cord and is a relatively rare,antigen-antibody-mediated,inflammatory demyelinating disease with recurrence.Aquaporin-4(AQP4)and myelin oligodendrocyte glycoprotein(MOG)antibodies are important biomarkers of NMO,and studies have not found the coexistence of the two.ObjectiveTo provide theoretical basis for the differential diagnosis of AQP4 and MOG antibody positive by imaging and electrophysiological comparative analysis of the two types of patients.Method1.Collect NMOSD patients hospitalized in the Department of Neurology of our hospital from May 2017 to July 2018,and retrospectively analyze their case data;2.The patients were divided into three groups by antibody detection: AQP4 antibody positive group and MOG antibody positive double negative group.3.Optical coherence tomography was used to analyze the NRFL thickness at 12 hours in the three groups of patients for the study of retinal damage characteristics;4.The dysfunction scale analyzes the degree of functional system disease in patients;5.MRI and visual evoked potential were used to detect the electrophysiological characteristics of the three groups of patients.Results1.A total of 100 NMOSD patients who met the study inclusion criteria were collected for study analysis in this study;2.According to the antibody detection criteria,the patients were divided into three groups:AQP4 antibody positive group(72 patients),MOG antibody positive group(19 patients)and double negative group(9 patients);3.The NRFL thickness of the three groups of patients,at different sites,the corneal thickness of the antibody-positive group was lower than that of the double-negative group,and the retinal thickness of the AQP4 antibody-positive group was lower than that of the MOG antibody-positive group;4.MRI results could not distinguish between the AQP4 antibody-positive group,the MOG antibody-positive group,as well as the double-negative group.VEP unilateral optic nerve damage as well as VEP latency prolongation were higher in the MOG antibody-positive group,which were significantly different from those in the AQP4 antibody-positive group of patients.Conclusion1.There is no significant difference in the general clinical characteristics between the AQP4 antibody positive group and the MOG antibody positive group;2.The retinal structure is related to the production of AQP4 antibody and MOG antibody in NMOSD patients.The production of antibody leads to retinal structure damage and thickness thinning.The degree of retinal damage in the APQ4 antibody positive group is stronger than that in the MOG antibody positive group;3.The VEP unilateral optic nerve damage and VEP latency prolongation are higher in the MOG antibody positive group,which is significantly different from the AQP4 antibody group and can be used as a means to identify and distinguish the production of two antibodies in NMOSD patients.