| Objective There are abnormalities in prefrontal cerebral blood flow in schizophrenics,and prefrontal lobe is the main brain area of cognitive impairment.At present,there are many researches on near-infrared spectral imaging with speech fluency test as the paradigm.There is a lack of research on near-infrared spectral imaging with Stroop as the paradigm for first-episode schizophrenics.There is also a lack of research on the characteristics of cerebral blood flow changes before and after treatment.Therefore,we use Stroop as the paradigm As a paradigm,we studied the distribution of prefrontal cerebral blood flow in patients with first-episode schizophrenia before and after treatment.Methods From August 2018 to December 2019,16 first-episode schizophrenics were selected from the acute intervention Department of Shenzhen Kangning hospital.At the same time,16 healthy people with age,education level and matched with the patient group were taken as the normal control group.Taking Stroop test as the task,FP1 and FP2 were set up with the international standard lead of EEG examination and distribution,and information receivers were set up in the prefrontal lobe at an interval of 3cm.The near-infrared spectrum data were recorded and analyzed before and after treatment in the normal group and the patient group before and after treatment.The patients group was given olanzapine [mean dose(17.78 ± 2.92)mg] for 4weeks.The near-infrared spectral imagingwas detected before and after treatment,once in the normal group,and positive and negative symptom scale(pans)were evaluated before and after treatment.SPSS 22.0 statistical software was used to analyze the experimental data.Paired t test was used for the measurement data in accordance with normal distribution.If there is a group that does not conform to the normal distribution,the paired Wilcoxon rank sum test is used for the comparison between the two groups.The difference was statistically significant(P < 0.05).Results Compared with the normal group before treatment,the changes of cerebral blood flow were summarized as follows.1.The levels of oxyhemoglobin(Oxy-Hb)in patients with CH2(channel two)and ch20 were lower than those in normal group before treatment;those in patients with ch1,ch20,ch21 and ch22 were lower than those in normal group after treatment,and those in CH2 group were lower than those in normal group,but the difference was not statistically significant.There was no significant difference in oxy HB before and after treatment.2.The levels of deoxyhemoglobin(De Oxy-Hb)in patients with ch9,ch11,CH12,CH15,Ch18 and CH19 before treatment were higher than those in normal group;those in ch9,ch11,CH12,ch13,ch13,CH15,ch16,ch17,Ch18,CH19 and ch20 after treatment were higher than those in normal group.Ch20 was higher after treatment than before.3.Total oxyhemoglobin(To Oxy-Hb): ch20 in the patient group was lower than that in the normal group before treatment,and the difference was statistically significant.The difference was not statistically significant.The difference was not statistically significant.Conclusion1.Before treatment,the activity of right dorsomedial area and right ventromedial area of PFC was low.After treatment,the right ventromedial area was improved,and the activity of this area might be a candidate state marker.There is a tendency to improve the activity of the right dorsomedial area,and its clinical significance needs further study.After treatment,there were new cortical areas with low activity: right dorsolateral area and left ventrolateral area,which suggested that olanzapine might be involved.2.In the patients group,blood flow slowed down in the right middle ventrolateral area,left and right middle area and left lateral area.After treatment,the areas of cerebral blood flow slowing down were further expanded into the right ventral medial and medial areas,and the left middle and ventral areas.It is suggested that the blood flow in this region tends to become slower after treatment,which may be related to the slowing down of blood flow caused by olanzapine.3.The amount of brain perfusion in the right ventral region is lower than that in the right frontal lobe after treatment.Therefore,the ability of anti-interference of Stroop related information in schizophrenic patients may be reflected in three aspects: 1.Low cerebral blood flow activity in right dorsomedial area and right ventromedial area;2.Slow cerebral blood flow in right middle ventrolateral area,left and right middle area and left lateral area;3.Low cerebral perfusion volume in ventromedial area of right prefrontal lobe. |
