Application Of Quantitative EEG Monitoring In Evaluating Thrombolytic Effect Of Acute Cerebral Infarction

Purpose:To explore the value of quantitative electroencephalogram(QEEG)in evaluating thrombolytic effect of acute cerebral infarction,and to provide clinical data for thrombolytic effect of acute cerebral infarction.Method:From January 2020 to December 2020,91 patients with acute cerebral infarction were treated with intravenous thrombolytic with recombinant tissue plasminogen activator(within 4.5h hours)in the emergency department of Qinhuangdao First Hospital.The relative energy values of δ,θ,α,β waves and corresponding(National Institute of Health stroke scale,NIHSS)scores of QEEG before thrombolytic,2 h,24 h and 7 d after thrombolytic were recorded respectively.By calculating the ratio of(δ + θ)wave to(α + β)wave(DTABR =(θ + δ/α +β)and the ratio of δ to α wave(DAR = δ/α),the change rule of DTABR and DAR ratio before and after thrombolytic and its correlation with NIHSS score were analyzed.Result:1.DTABR one-way variance analysisIn the thrombolytic effective group,the DTABR after thrombolytic was significantly lower than that before thrombolytic,and the DTABR at each time point after thrombolytic was statistically significant(P<0.05).After thrombolytic,there was no significant difference in DTABR between groups(P>0.05).In the thrombolytic ineffective group,the DTABR did not change significantly or increased after thrombolytic,and there was no significant difference between the DTABR after thrombolytic and before thrombolytic(P>0.05).After thrombolytic,there was no significant difference in DTABR between groups(P>0.05).2.Correlation between DTABR and NIHSSPearson correlation coefficient analysis suggested that the lower the NIHSS score,the lower the DTABR ratio,and the DTABR was positively correlated with NIHSS3.DAR one-way variance analysisIn the thrombolytic effective group,the DAR after thrombolytic was significantly lower than that before thrombolytic,and the DAR at each time point after thrombolytic was statistically significant(P<0.05);There was no significant difference in DAR between groups after thrombolytic(P>0.05).In the thrombolytic ineffective group,DAR did not change significantly or increased after thrombolytic.Except for the right thrombolytic ineffective group,the DAR value at the 7th day after C4 lead thrombolytic was significantly different from that before thrombolytic(P<0.05),there was no significant difference between the other time points after thrombolytic and before thrombolytic(P>0.05).After thrombolytic,there was no significant difference in DTABR between groups(P >0.05).4.Correlation between DAR and NIHSSPearson correlation coefficient analysis suggested that the lower the NIHSS score,the lower the DAR ratio,and the DAR was positively correlated with NIHSS.Conclusion:QEEG quantitative indicators DTABR and DAR can quickly,accurately and effectively evaluate the thrombolytic effect of acute cerebral infarction.