The Relationship Between Mutations In The Striated Muscle Preferentially Expressed Protein Kinase And Dilated Cardiomyopathy In Western Guangxi

Objective: To investigate the relationship between Dilated Cardiomyopathy(DCM)and SPEG gene mutations in western Guangxi.Methods:(1)According to the principle of knowing,83 DCM patients admitted to the Affiliated Hospital of Youjiang Medical College for Nationalities from October 2018 to December 2019 were selected as the experimental group.The 93 non-DCM patients who were hospitalized during the same period served as the control group.(2)Collect blood samples and general clinical data of patients in the DCM group and the control group,and perform DNA extraction,DNA concentration determination,PCR amplification,and product sequencing on the blood samples.(3)Analyze the correlation between clinical data,genotype,gene frequency and the onset of DCM through SPSS 19.0 software.Results:(1)Comparison of general clinical data between the DCM group and the control group found that age,gender,uric acid,creatinine,creatine kinase isoenzyme,lactate dehydrogenase,B-type natriuretic peptide,left ventricular ejection fraction,high-density lipoprotein,left ventricular end diastolic dimension,and left atrium systolic have statistical significance(P<0.05),while low-density lipoprotein Density Lipoprotein Cholesterol,total cholesterol,left ventricular posterior wall diastolic,interventricular septum diastolic and other indicators The difference was not statistically significant(P>0.05).Comparison of general clinical data between patients with SPEG gene rs116911250 site and no mutation in the DCM group found that the differences in UA,HDL,LVPWD were statistically significant(P<0.05),age,gender,BNP,Cre,CKMB,LDH1,BNP,LDL-C,TC,EF,IVSD,LVDd,the difference was not statistically significant(P>0.05).Logistic regression model analysis was performed,and the results showed that Age,UA,LVDd,EF and other indicators were independent risk factors for DCM.(OR=0.906,1.003,1.116,0.957;P= 0.002,0.038,0.005,0.037).(2)There was a statistically significant difference between the SPEG gene rs116911250 site mutation in the DCM group and the control group(P<0.05).(3)The difference between the gene frequency and genotype of SPEG gene rs202124859 and rs78622154 locus and the control group was statistically significant(P<0.05),and the difference between the gene frequency and genotype of rs778763880 locus and the control group was not statistically significant.Significance(P>0.05).Conclusion:(1)This study found that the SPEG gene rs116911250 mutation may be a risk factor for DCM in western Guangxi.(2)SPEG gene rs202124859 and rs78622154 polymorphisms may be related to the onset of DCM in the population in western Guangxi.(3)The relationship between the polymorphism of the rs778763880 locus of the SPEG gene and the incidence of DCM in the population of western Guangxi is not yet clear.