Clinical Characteristics Analysis Of COVID-19 Patients With Renal Injury In Chong Qiong

Background This study aimed to identify the basic information and clinical characteristics of COVID-19 patients with renal injury in Chongqing,China.Methods Using a multi-center retrospective clinical study,we collected the information of patients with definite diagnosis of COVID-19 from the case systems of two designated hospitals from January 2020 to May 2020 in Chongqing,including some clinical symptoms,laboratory indicators and treatment methods.Logistic regression analysis was performed to analyze the risk factors affecting renal function.Results We collected data from 514 COVID-19 patients,eventually462 patients were included,the median age was 48(38-56)years,51.9%were male,and the overall mortality rate was 1.1%.During hospitalization,renal dysfunction occurred in 9.7% of the patients,10.3%(4/39)in severe cases and 28.6%(6/21)in critical cases,with a median time of 3(1-7)days.The mortality rate of patients with renal dysfunction was significantly higher than normal group(6.7%vs0.5%,P=0.008),and 40%(18/45)did not recover at the end point of observation.At the same time,we analyzed patients with urine samples and found higher rates of hematuria(39.0% vs.6.4%)and proteinuria(13.6% vs.11.6%)in patients with renal dysfunction.The overall incidence of AKI was about 1.7% and the mortality rate was37.5%.In critically ill patients,28.6% had AKI,and the mortality rate of such patients was 100%.Renal dysfunction was significantly correlated with gender and CRP value(P < 0.05).Binary Logistic regression analysis showed that CRP was an independent risk factor for renal dysfunction.Conclusion The incidence of COVID-19 with renal injury was not high in Chongqing.However,combined renal dysfunction was associated with the severity of the disease and high mortality during hospitalization.