Effect Of Omega-3 Fish Oil Fat Emulsion On The Immune Function Of Postoperative Rectal Cancer Patients

Objective To investigate the application value of omega-3 fish oil fat emulsion in postoperative parenteral nutrition support for patients with rectal cancer.Methods A total of patients with rectal cancer perpared to undergo radical surgery in our hospital from Apil July 2020 were slected devided into experimental group and control group according to the envelope method,30 cases in each group.The patients in both groups were treated short-term parenteral nutritional support therapy after surgery.while those in the control group were given a conventional nutrition scheme,on this basis,the experimental group was supplemented with an additional 10percent omega-3 fish oil fat emulsion for five days.In the early morning of the postoperative first,third,fifth day,the blood samples were collected respectively from the elbow vein of the patients in the two groups were taken to detect the cellular immune function（total number of peripheral blood lymphocytes,T lymphocyte subsets:CD₃⁺,CD₄⁺,CD₈⁺,CD₄⁺/CD₈⁺）,humoral immune function（serum immunoglobulin Ig A,Ig G,Ig M）,and the expression level of CD₁₄⁺monocyte surface antigen HLA-DR.Meanwhile,the incidence of postoperative infectious complications was recorded.Results On the first day after the surgery,there was no statistically significant difference in the cellular and humoral immune function between the two groups（P>0.05）.On the third and fifth day after the surgery,the total lymphocyte count,CD₃⁺,CD₄⁺levels,and CD₄⁺/CD₈⁺in the two groups showed an increasing trend,while the CD₈⁺level in the two groups presented a decreasing trend the change range of the experimental group was more significant than that of the control group,and the differences were statistically significant among groups,time points,and intergroup-time points（P<0.05）.After five consecutive days of parenteral nutrition support,the positive expression rate of CD₁₄⁺monocyte surface antigen HLA-DR in the experimental group was（68.10±3.25）%,which wsa significantly higher than（64.35±3.03）%in the control group（P<0.01）.The positive expression rate of monocyte surface antigen HLA-DR in the experimental group on the fifth day after the surgery was also significantly higher than that on the first and third day after the surgery,but no difference was found in the control group（P>0.05）.Infectious complications occurred in both groups after the surgery,and the incidence of infectious complications in the experimental group was similar to that in the control group,because the difference was not statistically significant（20.00%vs 30.00%,c2=0.800,P=0.371）.Conclusions The reasonable addition of omega-3 fish oil fat emulsion to the postoperative parenteral nutrition programs for patients of rectal cancer can improve their immune function,reduce infectious complications,and may be helpful to the prognosis.