Exploring The Neurophysiological Mechanism Of The Treatment Of Cervical Vertigo Based On Functional Magnetic Resonance Brain Function Imaging

Objective:The functional magnetic resonance imaging(fMRI)technology based on ratio low frequency oscillation amplitude(f-ALFF)is used to observe the brain function status of patients with cervical vertigo at rest,and the immediate effect and before and after treatment of the treatment of cervical vertigo with the sinew-regulating and bone-setting Changes of brain function in resting state,to explore the mechanism of the treatment of cervical vertigo by strengthening the bones and muscles.The functional magnetic resonance imaging(fMRI)technology based on ratio low frequency oscillation amplitude(f-ALFF)is used to observe the brain function status of patients with cervical vertigo at rest,and the immediate effect and before and after treatment of the treatment of cervical vertigo with the manipulation of muscles and bones Changes of brain function in resting state,to explore the mechanism of the treatment of cervical vertigo by sinew-regulating and bone-setting.Methods:Twenty-two patients with cervical vertigo(treatment group)and 21 healthy people with matching age,course of disease,and educational background(control group)were recruited as observation objects.The treatment group was treated with the sinew-regulating and bone-setting once,and the control group was not treated.The treatment group was assessed by the Cervical Vertigo Symptoms and Function Assessment Scale(ESCV),pain VAS,and vertigo VAS scores before and after treatment.All subjects underwent resting-state fMRI data collection for the whole brain function,and CV patients The functional magnetic resonance data acquisition was performed after one treatment of sinew-regulating and bone-setting.Based on the MATLAB R2018a platform,the CONN data analysis software was used to perform two independent sample t-tests on the CV patients and the normal group to obtain fALFF difference brain areas,and the paired sample t test was used to compare the fALFF difference brain areas of the whole brain before and after treatment;Correlation analysis between brain fALFF and clinical indicators.Results:After treatment in the treatment group,the ESCV score increased compared with that after the treatment,and it was statistically significant(P<0.05),the pain VAS and vertigo VS A scores decreased,and the degree of decline was different than before the treatment(P<0.05);In the CV patient group before treatment,compared with healthy people,the brain regions with enhanced f-ALFF values are:cerebellar 1/2,brainstem,precuneus,right lateral occipital cortex/right middle temporal gyrus,right Lateral superior lobule;brain regions with enhanced f-ALFF value(uncorrected,P<0.005,cluster≥100)are:thalamus,right superior frontal gyrus/right middle frontal gyrus,left superior frontal gyrus,left Frontal pole(uncorrected,P<0.005,cluster block≥100).Comparison of f-ALFF values before and after treatment in CV patients.The brain areas that enhance the signal after treatment are:right cerebellar 1/2 area,right inferior temporal gyrus/middle temporal gyrus,brain stem,bilateral cerebellum 9 areas,Right parahippocampal gyrus,left inferior temporal gyrus/middle temporal gyrus,and right cerebellar area 1(uncorrected,P<0.005,cluster≥40);brain areas with f-ALFF value postoperatively showing weakened signals are:The fusiform gyrus of the right temporo-occipital,the right middle temporal gyrus/right lateral occipital cortex(uncorrected,P<0.005,cluster≥40).Correlation between the whole brain fALFF value and clinical indicators of CV patients before treatment:The whole brain fALFF value is positively correlated with the course of the disease.Brain regions include:right temporal pole,right precuneus,anterior cingulate gyrus,left inferior temporal gyrus,Left anterior cuneiform lobe;negatively related brain areas include:left cerebellar area 1,2 and right cerebellar area 1,2(uncorrected,P<0.005,clusters≥20);brain areas that are positively correlated with pain VAS scores:Right frontal pole,right middle frontal gyrus,right cerebellum 6,left tectum,left central anterior gyrus(uncorrected,P<0.005,cluster≥20);brain areas are positively correlated with vertigo VAS score:Right parahippocampal gyrus,right lateral occipital lobe;negatively related brain areas:left temporal pole,right frontal pole(uncorrected,P<0.005,cluster≥20).Conclusion:sinew-regulating and bone-setting can immediately and effectively reduce the dizziness and neck and shoulder pain of CV patients.Manipulative treatment is effective for the right cerebellar 1/2 area,the right inferior temporal gyrus/middle temporal gyrus,brain stem,and bilateral cerebellum in CV patients 9 Areas,right parahippocampal gyrus,left inferior temporal gyrus/middle temporal gyrus,right cerebellar area 1,right fusiform gyrus of temporo-occipital,right middle temporal gyrus/right lateral occipital cortex,these brain areas play a role.