Effects Of Different Blood Pressure Status On The Cognitive Function And Cardiovascular Disease Risk Of Workers Exposed To Polycyclic Aromatic Hydrocarbons

Objective:(1)Explore the interaction between the of occupational PAHs exposed workers and different blood pressure states of cognitive function and cardiovascular disease risk;(2)Explore the association of cognitive function and urinary PAH metabolites in workers with different blood pressure states,Explore the association of cardiovascular disease risk and urinary PAH metabolites in workers with different blood pressure states.Methods:Recruit 610 workers from a coking plant in Taiyuan City.There were 454 workers in the same group of water treatment plants.We obtained informed consent from 1,046 workers in the two plants,then We collected general information about the workers.We use the Montreal Cognitive Assessment Scale to measure workers’ cognitive function,workers’ score less than 26 is considered to be mild cognitive dysfunction,the risk of cardiovascular disease,we use the China-PAR,higher than0.05 are high-risk groups.we also measure the content of OH-PAHs in the urine of workers,and divide the workers into 3 groups: prehypertensive group,normal blood pressure group,hypertension group,using multiple linear regression model,Logistic regression model to detect the relationship between polycyclic aromatic hydrocarbon metabolites in urine and hypertension status,cognitive ability and cardiovascular disease risk,and whether there is any interaction.use Sexual cubic spline model to fit relationship.Results:Occupational workers pre-hypertension accounted for a high proportion of all workers.Coking plants accounted for 62.1%,and water treatment plants accounted for 65.6%.The MCI detection rate and cardiovascular disease risk in the coking plant population are positively correlated with blood pressure.The same situation did not occur in the power plant.We did the interaction(p<0.05).Logistic analysis was conducted for the two plants.In the unadjusted model,The results are as follows:power plant: prehypertension0.909(0.509,1.625),hypertension:0.836(0.399,1.725),the results after adjusting the covariates are not much different from those before the adjustment.Coke oven plant: 1.698(1.001,2.882),which becomes1.322(0.759,2.302)after adjustment.we use total score of the Mo CA,and the 11OH-PAH metabolites were converted into a multivariate regression model by natural logarith MCI transformation,and the covariates were adjusted.The coking plant workers were grouped by blood pressure for linear regression,OH-NAP2 In the prehypertension group,there is a linear relationship with the total score of the Mo CA scale.If OH-NAP2 increases by a natural logarith MCI unit,the total score of the Mo CA scale decreases by 0.21(P=0.02).normal blood pressure group: 0.37(P=0.049)for every increase of a natural logarith MCI unit.After that,the RCS model was used to test whether there was a nonlinear relationship.Both the normal blood pressure group and the prehypertensive group showed no non-linear relationship(p for non-linear association=0.6540 p for non-linear association=0.9907).Table 2 shows that occupational exposure to polycyclic aromatic hydrocarbons and blood pressure status may have an interactive effect on the risk of cardiovascular disease.Workers are divided into 3 groups.0.05 was selected as the defined value,and workers’ cardiovascular disease risk scores were converted into categorical variables,and they were divided into low-risk groups(<0.05)and high-risk groups(≥0.05).The same results were obtained.After that,the occupational workers of the two factories as a whole were grouped by blood pressure to do multiple linear regression with urine OH-PAHs.For every e unit increase in the concentration of 2-OHFlu in the urine of workers,the risk of prehypertensive workers becoming a high-risk group of cardiovascular disease increased by 1.758 times(95% confidence interval 1.267,2.439),and for every e increase in the concentration of 9-OHPhe in the urine of workers Workers in the prehypertensive state per unit have an increased risk of becoming a high-risk group of cardiovascular disease by 1.554(95% confidence interval 1.065,2.268).When the concentration of 1-OHPhe in the urine of workers increases by e times,workers in the prehypertensive state become high-risk for cardiovascular disease The population risk increased by 1.420 times(95% confidence interval 1.106,1.822)and the same situation was not found in other blood pressure groups.Conclusion:1.Under occupational exposure to polycyclic aromatic hydrocarbons,blood pressure is related to the detection rate of MCI.The higher the blood pressure,the higher the detection rate of MCI.2.In the prehypertensive state,there is a linear relationship between urine OH-PAHs and the total score of Mo CA and the population at risk of cardiovascular disease.