Changes Of Topological Attributes Of Brain Functional Network In Patients With Cerebral Small Vessel Disease And The Relationship With Cognition

Objective:To compare the global and local parameters of brain function network between patients with cerebral small vessel disease(CSVD)and healthy control group,and to evaluate the correlation between different parameters and cognitive function.Methods:19 patients with CSVD(white matter lesion complicated with lacunar infarction)were collected,and 20 healthy elderly were recruited.the cognitive scales were used to evaluate their overall cognition,memory,attention,executive function and other cognitive domains.At the same time,resting functional magnetic resonance imaging and data acquisition were completed.Then,the undirected brain function network was constructed by Gretna software,and the global and node network attribute values were calculated.Appropriate statistical methods were used to compare the area under each network parameter curve between groups,and to evaluate the correlation between global network attributes,some node parameters and cognitive scores in CSVD group.Results:There is a significant difference in local network efficiency between CSVD group and control group(P<0.05),but there is no significant difference in other overall network indicators(including global network efficiency,small-world attributes such as γ,λ,clustering coefficient,σ,etc.)(P>0.05).The analysis of the node network shows that the node parameters(including node clustering coefficient,node efficiency and shortest path length)of some nodes in CSVD group are obviously different(P<0.05),and it is found that the node efficiency of some nodes has a significant positive correlation with cognitive functions in different cognitive domains(P<0.05).Conclusion:Compared with healthy elderly people,CSVD patients not only have significant damage to global brain function network,but also show significant differences in brain function network at some nodes,which may be closely related to cognitive impairment and dementia.