Expression And Correlation Study Of Forkhead Box Protein C2 In Endometrial Adenocarcinoma

Objective:To investigate the expression of forkhead box protein C2(FOXC2)in endometrioid adenocarcinoma(EAC)and adjacent normal endometrial tissues,and to analyze the relationship between the expression of FOXC2 in EAC and pathological characteristics.Methods:From May 2019 to October 2020,56 patients with endometrioid adenocarcinoma diagnosed by pathology after surgical treatment were selected from the first hospital of Shanxi Medical University.The clinical records of the selected patients were complete,and they did not receive radiotherapy or chemotherapy before operation,and were not combined with other malignant tumor history.The cancer tissue and normal adjacent endometrial tissue were embedded in paraffin.Through immunohistochemical detection of FOXC2 in cancer tissue and normal adjacent endometrial tissue,to explore the relationship between the expression of FOXC2 in cancer tissue and pathological characteristics,the data were obtained by spss26.0software.Results:1.The main expression position of FOXC2 was in cytoplasm,a small amount in the nucleus,and the high expression rate in EAC was 66.07%,21.43% in the normal peri cancer intima tissue,the difference was significant(P < 0.05);2.FOXC2 expression in EAC was related to histological grade,clinical pathological stage and lymph node metastasis,and the difference was statistically significant(P<0.05).There was no significant correlation with the depth of myometrium infiltration,whether menopause and diabetes were combined at the same time,and there was no significant difference between the two groups(P > 0.05).Conclusion:FOXC2 showed a higher expression level in cancer tissues,and the difference was significant compared with the adjacent tissues.The expression level was correlated with histological grade,clinicopathological stage and lymph node metastasis,but not with the depth of myometrial invasion,menopause and diabetes.These results suggest that FOXC2 may play a key role in the progression of endometrioid adenocarcinoma,or provide a new target for immunotherapy.