Comparison Of Serum IGFBP7 Levels In Colorectal Cancer And Colorectal Polyps

Objective:This study aims to evaluate whether there is a difference between serum insulin-like growth factor binding protein 7(IGFBP7)in colorectal cancer(CRC)and colon polyps,and to further explore the possible clinical significance of serum IGFBP7 in colorectal cancer.Methods:Serum IGFBP7 levels were detected by enzyme-linked immunosorbent assay(ELISA)in CRC patients without anticancer treatment(n=46),patients after radical CRC surgery(n=20)and patients with colorectal polyps(n=20),and the differences of levels among the groups were compared.Receiver operating characteristic(ROC)curve,area under ROC curve(AUC),sensitivity and specificity were used to analyze its diagnostic potential.The relationship between the positive rate of serum IGFBP7 and the clinicopathological characteristics was analyzed by x~2 test to further explore its clinical significance.Results:The level of serum IGFBP7 in colorectal cancer patients without anticancer treatment was significantly higher than that in benign polyp group(P<0.05).When the optimal cut-off value was 4.274ng/m L,IGFBP7 showed certain diagnostic potential in CRC with a sensitivity of 67.4%,a specificity of 80%,and an area under ROC curve(AUC)of 0.720.When IGFBP7 was used in combination with CEA in the diagnosis of CRC,the sensitivity increased to 89.1%and the AUC was 0.812.There was no significant correlation between IGFBP7 and various common clinicopathological features(P>0.05).serum IGFBP7 levels in patients with CRC were decreased with stage increase.Conclusion:The serum IGFBP7 in CRC patients is significantly higher than that in colorectal polyps,and IGFBP7 may play a certain biological role in the development of colorectal cancer.Serum IGFBP7 may be a potential diagnostic biomarker for colorectal cancer,and can improve diagnostic accuracy when combined with CEA.