| Objective: Abnormal sperm morphology was one of the important reasons for the failure of natural conception,and assisted reproduction is used as a primary treatments at present.Through a systematic review this paper was to definite the effect of normal sperm morphology rate(NSMR)on the pregnancy outcome of intrauterine insemination(IUI),in vitro fertilization-embryo transfer(IVF-ET)and intracytoplasmic sperm injection(ICSI),so as to provide the reference basis for improving the success rate of assisted reproduction.Methods: In this paper,The literatures were searched from the databases in both English and Chinese after searching Pubmed,Embase,Cochrane,Web of Science,CNKI,Wanfang,VIP and other Chinese and English databases.Then the data were selected and extracted according to inclusion and exclusion criteria,and the quality of research methodology was evaluated by reviewers.The STATA 12.0 software was used for Meta-analysis.Results: 20 studies including 11 588 cycles were included.The results of Meta-analysis showed that the fertilization rate(RR = 0.95,95% CI: 0.92-0.97)and ICSI fertilization rate(RR = 1.02,95% CI: 1.00-1.04)were statistically significantly different between NSMR≥4%and < 4%(P<0.05),and there was no statistical significance of NSMR for the clinical pregnancy rates of IUI,IVF,ICSI and the abortion rates of IVF,ICSI(P > 0.05).Conclusions: The NSMR has significant influence on the fertilization rate of IVF and ICSI,but it has no significant influence on the clinical pregnancy rate of IUI,IVF,ICSI and the abortion rate of IVF and ICSI.Low NSMR was associated with an increased risk of fertilization of IVF and ICSI.And the NSMR was significant for predicting the outcome of assisted reproductive. |
PDF Full Text Request