Application Of Photothermal Inorganic Nanoparticles In Periprosthetic Joint Infection

Background and purpose:Periprosthetic infection is a serious complication of orthopedic surgery.The formation of biofilm can establish physical and chemical barriers to protect bacteria from exogenous antibiotics and endogenous host immune system.Such biofilms are the major factors that contributes to the failure of antibiotics treatment.The long-term existence of biofilm which makes bacteria can not be completely removed,repeated infection and affecting tissue unhealing.At the same time,antibiotics abuse will also produce systemic side effects.Therefore,exploiting novel antibacterial agents which can effectively remove biofilm and have little side effects is extremely urgent.Methods:Tailored to the biofilm microenvironment,we designed and synthesized polyoxometalates and copper ions doped polyoxometalates with photothermal properties and Fenton reaction catalytic activity.The effects of photothermal therapy and chemical dynamic therapy were verified by in vitro material characterization experiment and in vitro antibacterial experiment.Results:After reduction by GSH,POM and Cu POM can show obvious absorption peak in NIR I region,good photothermal effect and catalytic activity for Fenton reaction.POM has good antibacterial efficiency of photothermal therapy in vitro antibacterial experiment,while Cu POM has the synergistic more better antibacterial efficiency of photothermal therapy and chemical dynamic therapy.Conclusion:POM and Cu POM reduced by GSH have good photothermal therapy effect,and the Fenton catalytic activity was enhanced by Cu POM.The synergistic antibacterial effect of photothermal therapy and chemical dynamic therapy of Cu POM is more efficiency than that of single model.