Analysis Of Pre-operative Related Factors Of Breast Tumors And Correlation Between TCM Syndrome Types And Immune Indexes

Objective: To observe the differences and similarities of various factors of benign and malignant breast tumors before operation and the distribution law of TCM syndrome types,which plays a role as a guidance for the primary and secondary phase of breast cancer prevention and treatment.Meanwhile explore general rules of the prognosis among various TCM syndromes in breast cancer.Methods: A total of 135 patients with breast cancer who were about to undergo surgical treatment were collected from December 2019 to November 2020 in the Breast Surgery Department of The Affiliated Hospital of Hebei University.Information collection was conducted in two parts for patients who met the inclusion criteria,including pre-operation TCM syndrome collection,post-operation immune pathology information collection,and recorded in a unified format Excel spreadsheet,forming the basic information database.According to the clinical significance and the basic theory of traditional Chinese medicine,by analyzing and discussing the differences,the results are summarized and the laws are summarized.Results: 1.A total of 135 preoperative patients with breast tumors were screened out,all of them were women,among which the youngest was 16 years old and the oldest was 79 years old,with the average age of 50.60±12.47 years old.There were 42 cases(31.10%)of benign breast tumors and 93 cases(68.90%)of malignant breast tumors.2.Comparison and analysis of the differences in the incidence of benign and malignant breast tumors under different factors showed that there were differences between groups in educational level,occupation,family economic relationship,family atmosphere,work atmosphere,the situation of independent evaluation of confinement,and the previous history of benign breast diseases between benign and malignant tumors(P<0.05).To further evaluate its correlation with the occurrence of benign and malignant breast tumors.The overall test results of the model showed that the chi-square value was 48.98,P<0.05,indicating that the logistic model was statistically significant.Patients with a previous history of breast benign disease who had a preoperative breast tumor had a 4.5690-fold higher risk of developing a nausea tumor than patients without a related history of disease.3.135 cases: 105 cases(77.78%)with stagnation of liver-qi and phlegm,27 cases(20.00%)with mutual accumulation of phlegm and blood stasis,and 3 cases(2.22%)with disorder of thoroughfare and conception vessels.Differences in various factors of preoperative traditional Chinese medicine syndrome types of breast tumors show that significant differences exist among groups with previous history of benign breast diseases(P=0.0006),accumulated scores of nodules in other organs(P=0.0256)and mass size(P=0.0178).Pairwise comparison showed that the differences between the liver stagnation and phlegm coagulation syndrome group and the phlegm and blood stasis stagnation syndrome group were statistically significant(P<0.05).4.The syndrome of liver stagnation and phlegm stagnation has the largest number of patients with breast tumors(105 cases),and is the only common syndrome type of benign and malignant.To compare the similarities and differences of liver stagnation and phlegm coagulation syndrome before operation between benign and malignant breast tumors: There was a difference in age distribution between malignant and benign liver stagnation and phlegm coagulation syndrome(P<0.05).Differences existed between malignant and benign tumors of liver stagnation and phlegm stagnation syndrome in education level,family atmosphere,work atmosphere,independent evaluation of confinement,distribution location of the mass,presence of previous history of benign breast diseases,BI-RADS classification and mass size,P<0.05.5.There are differences in the detection methods of various TCM syndrome types of breast cancer before surgery,P<0.05.Pairwise comparison results show that there is a difference in the way of discovering liver stagnation and phlegm coagulation and phlegm stasis(P=0.0238).After breast cancer surgery,tumor histological grade,molecular typing,tumor estrogen receptor(ER)expression,tumor progesterone receptor(PR)expression,oncogene epidermal growth factor receptor(Her-2)expression,The expression of proliferating cell nuclear antigen(Ki-67),P120 ctn catenin(P120ctn),GATA binding protein3(GATA3),giant cyst disease liquid protein-15(GCDFP-15)before surgery There was no statistical difference in the expression differences between the syndromes and Chong-Ren disorders,and the logistic model was not statistically significant.Conclusion:1.Among the influencing factors and diagnostic factors,it was found that breast cancer patients who worked as farmers and had education at college or above had a higher risk of breast cancer;Women and men who share the burden of family economy,have a harmonious understanding of social life and a high level of self-evaluation.Patients with breast cancer have a good prognosis and can reduce the risk of breast cancer.2.Phlegm and blood stasis syndrome is mostly blood stasis syndrome,which develops from blood stasis syndrome and has a certain course of disease development.Therefore,the medical history of phlegm and blood stasis syndrome in benign breast diseases is higher than that in liver depression and phlegm and blood stasis syndrome;The scores of nodules or/and cysts in the syndrome of liver-qi stagnation and phlegm coagulation were more than those in the syndrome of phlegm and blood stasis mutual stagnation.Therefore,from the initial stage of qi accumulation,the nodules or/and cysts were scattered and multiple along the meridian,and the disease lasted for a long time from qi to blood.Nodules decreased,but the mass and volume increased.3.The largest number of patients with breast tumor was in the syndrome of liver stagnation and phlegm stagnation(105 cases),and it was the only common syndrome type of good and malignant.Women with lower and higher education,a history of benign breast diseases,a higher BI-RADS classification and a larger mass in this syndrome are at higher risk for breast cancer.Patients who self-perceived the harmonious social life,had the specially-assigned person to take care of it,the matching of meat and vegetable diet,the well-regulated nursing process of confinement,and the patients with bilateral and multiple mass distribution had relatively low risk of breast cancer.4.This study has shown that there is no significant correlation between the pre-operation TCM syndrome types of breast tumors and immunopathological indexes,so it is impossible to explicitly assist TCM syndrome differentiation from the perspective of micro-biology,and realize the micro-syndrome differentiation of TCM syndrome.