Association Between Serum High Sensitivity C-Reactive Protein And Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Objective:At present,the non-invasive detection field of NAFLD has yet to be explored,so this study evaluated the relationship between serum high sensitivity c-reactive protein(HS-CRP)and nonalcoholic fatty liver disease(NAFLD)by meta-analysis system.To provide a new clinical reference for the non-invasive detection field of NAFLD.Methods:PubMed,EMbase,The cochrane library,CNKI,Sino Med and Wan Fang Data were electronically searched to collect case-control studies on the association between HS-CRP and NAFLD from inception to October,2019.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies,then,meta-analysis was performed by using Rev Man 5.3 software.Results:The results of meta-analysis showed that HS-CRP levels in NAFLD group was higher than non-NAFLD group(SMD=1.25,95%CI 0.81 to 1.68,P<0.000 01),the difference was statistically significant.The results of subgroup analysis showed that,HS-CRP levels in NAFLD group was higher in Asian region(SMD=1.32,95%CI0.82 to 1.83,p<0.000 01),but not in Americas region(SMD=0.48,95%CI-0.02 to0.98,P=0.06).HS-CRP levels in NAFLD group was higher in BMI≥30kg/m2 group(SMD=0.37,95%CI 0.19 to 0.54,P<0.000 1),but not in BMI<30kg/m2 group(SMD=1.19,95%CI-0.28 to 2.66,p=0.11).And the hs-CRP level was higher in NAFLD group regardless of whether the general population had diabetes(SMD=0.86,95%CI 0.49 to 1.24,p<0.000 01;SMD=1.47,95%CI 0.84 to 2.10,P<0.000 01).Conclusion:Current evidence shows that NAFLD patients have higher levels of HS-CRP than non-NAFLD patients,and it affected by high levels of BMI and geographical regions.Therefore,HS-CRP maybe play an important clinical value in the non-invasive field of NAFLD detection.Due to limited quality and quantity of the included studies,more high quality studies are needed to verify above conclusion.