Changes Of Caveolin-1、VE-cadherin、CXCL8 And CXCL9 In Cerebrospinal Fluid Of Children With Central Nervous System Infection

Objective: To detect the contents of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in cerebrospinal fluid of children with central nervous system infection(CNS),and to explore the role of their content changes in CNS infection,so as to provide a new basis for early recognition of CNS infection.Methods: Selection in October 2018 to November 2020 in the first hospital pediatric clinic of handan city and 35 cases of viral encephalitis(VE)in children with purulent meningitis(BM)in children with 32 cases,24 cases of the central nervous system infection children as control group.Cerebrospinal fluid(CSF)of children in acute stage,VE group and BM group were collected during acute stage and after treatment.The levels of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in CSF of children in control group were detected by ELISA.IBM SPSS V24.0 software was used to conduct one-way ANOVA for each group.LSD-t test was used for pair comparison within the group,and t-test was used for comparison of each group at acute stage and after treatment to analyze the level changes of each group.The correlation between Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in acute phase was analyzed by Pearson test.Get down to the level of 0.05Results:1.In the acute stage,the levels of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in cerebrospinal fluid in BM and VE groups were higher than those in the control group,and the differences were significant.Caveolin-1,VE-cadherin and CXCL8 in BM group were higher than those in VE group,and the difference was statistically significant.CXCL9 in VE group was higher than that in BM group,and the difference was statistically significant.2.After treatment,the levels of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in the cerebrospinal fluid of the children were compared between the BM group and the VE group,and the differences in the levels of Caveolin-1 were statistically significant,while the differences in the levels of VE-cadherin,CXCL8 and CXCL9 were not statistically significant.3.The levels of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in cerebrospinal fluid in BM and VE groups were all higher at acute stage than those after treatment,and the difference was statistically significant.4.Caveolin-1,VE-cadherin and CXCL8 in cerebrospinal fluid were positively correlated with each other,and negatively correlated with CXCL9.Conclusions:1.Caveolin-1,VE-cadherin,CXCL8 and CXCL9 are all involved in the pathogenesis of central nervous system infection.The expression level of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in acute phase can provide basis for early identification of central nervous system infection.2.The levels of Caveolin-1,VE-cadherin,CXCL8 and CXCL9 in the cerebrospinal fluid of children with central nervous system infection are different at the acute stage and after treatment.Dynamic detection of the levels of cerebrospinal fluid in children with central nervous system infection is of guiding significance for the observation of the efficacy of children with central nervous system infection.