The Correlation Study Of TCM Syndrome Elements,Inflammatory Indexes And Prognosis Of Diffuse Large B-Cell Lymphoma

Objective: To analyze the distribution of TCM syndrome elements(qi deficiency,yin deficiency,phlegm,blood stasis,qi stagnation,cold coagulation)in newly diagnosed patients with diffuse large B-cell lymphoma through cross-sectional research,and the combination of TCM syndrome types,and The relationship between the two and general conditions(age,gender),some inflammation indicators,and the relationship between syndrome elements,syndrome types,some inflammation indicators and prognosis are analyzed.Method:(1)Through the questionnaire survey form,collected the data of the fourth diagnosis of Chinese medicine for 79 newly diagnosed DLBCL patients,and summarized the distribution of the TCM syndrome elements of each patient and the combination of TCM syndrome types.(2)Record the patient’s gender,age,IPI score,fibrinogen,D-dimer,neutrophil count,lymphocyte count,monocyte count,serum albumin value,etc.,and calculate the relevant composite index,The IPI groups were divided into low-risk groups(low-risk groups,low-medium-risk groups)and higher-risk groups(medium-high-risk groups,high-risk groups).(3)Use SPSS23.0 software for statistical analysis:(1)Analyze the relationship between the inflammation index and the new IPI group,calculate the best cut-off value,and verify the prognostic value of the inflammation index in DLBCL patients;(2)Analyze the general conditions(age,Gender),the relationship between inflammation indicators and TCM syndrome elements and TCM syndrome types,to study TCM syndrome elements and the influencing factors of TCM syndrome types.Result:(1)A total of 79 patients were collected,including 42 males(53.16%)and 37 females(46.84%).The age group was "40 years <age ≤ 60 years" the most,with a total of 40 cases(50.63%);IPI The "low-risk group" is the most grouped,with 30 cases(37.97%)in total.(2)The distribution of the scores of the syndrome elements in 79 patients: "phlegm knot" is the most common at 3 points,and there are 54 cases(68.35%)in total.The most common type of TCM syndrome is cold phlegm stagnation,with 41 cases(51.90%).(3)(1)There is no significant correlation between "gender" and the scores of TCM syndrome elements;(2)"Age" is significantly positively correlated with the scores of "Qi Deficiency" and "Yin Deficiency".(4)The multiple logistic regression analysis of inflammation indicators and TCM syndrome elements showed:(1)The smaller the prognostic nutritional index value,the more serious the patient’s "Qi deficiency" and "Yin deficiency";(2)The larger the D-dimer value,the more severe the patient’s "D-dimer" value."Blood stasis" is more serious.(5)Binary logistic regression analysis of inflammation indexes,general conditions and TCM syndrome types:(1)For every increase in prognostic nutritional index by 1 unit,the patient’s manifestation of Qi and Yin deficiency syndrome decreases by 13.70%;(2)D-dimer increases every time 1 unit,the patient’s manifestation of Qi deficiency and blood stasis syndrome increased by 29.00%.(6)The relationship between inflammation indicators and IPI low-risk group(low-risk group,low-medium-risk group),and higher-risk group(medium-high-risk group,high-risk group):(1)There is no significant correlation between fibrinogen and the new IPI group;(2)D-dimer,NLR,LMR,PLR,prognostic nutritional index and other indicators are significantly correlated with the new IPI group.(7)Correlation between the scores of TCM syndrome elements and IPI grouping: "Qi deficiency" and "blood stasis" are all significantly positively correlated with "IPI grouping".(8)Correlation between TCM syndrome types and IPI grouping: "Qi deficiency and blood stasis syndrome" is significantly positively correlated with IPI grouping.In conclusion:(1)The most common syndrome element of DLBCL in TCM is "phlegm congestion",and the most common TCM syndrome is "cold phlegm stagnation syndrome".(2)The prognostic nutritional index,D-dimer and other inflammatory indicators can respectively reflect the severity of the patient’s "qi deficiency","yin deficiency",and "blood stasis",and assist in "qi deficiency and blood stasis syndrome" and "qi and yin deficiency syndrome".The identification of "" can provide a reference for TCM differentiation of patients with DLBCL in clinical practice.(3)Some inflammatory indicators have a certain correlation with the IPI grouping of DLBCL.(4)"Qi deficiency and blood stasis syndrome" may be related to the poor prognosis of DLBCL patients.