To Investigate The Relationship Between Cartilage Damage And Bone Mineral Density In Knee Osteoarthritis Based On The Theory Of Hepatorenal Homology

Objective:to analyze the relationship between the cartilage damage grade and bone mineral density of knee osteoarthritis and discuss the rationality of preventing and treating cartilage degeneration by improving bone mineral density in the early period of the knee osteoarthritis.At the same time,it provided a clinical research basis for Chinese medicine to treat knee osteoarthritis and osteoporosis with different diseases according to the theory of the theory of hepatorenal homology.Methods:We selected 30 patients with knee osteoarthritis of liver and kidney deficiency who met the diagnostic criteria and were admitted to the fifth department of bone injury,affiliated hospital of jiangxi university of traditional Chinese medicine from September 2017 to January2020,then collecte their age,sex,height,weight and other general information.Using an X-ray bone mineral density meter to measure their bone mineral density of the spine(The 1st lumbar to the 4th lumbar,and the result is expressed in terms of T),Magnetic resonance imaging(mri)was used to collect the grading of cartilage injury in the affected knee joint of all enrolled patients(Recht standard),Two deputy chief physicians were invited to evaluate the grading of cartilage injury in the knee joint,If there is a dispute between the two doctors,we should Consult a high-level imaging diagnostic physician to assist in diagnosis,Finally,the collected data was recorded and analyzed statistically with the help of SPSS21.0 statistical software.Results:1.In this study,we collected a total of 30 cases of knee osteoarthritis with liver-kidney deficiency,There were 8 male patients,accounting for 26.7%,There were 22 female patients,accounting for77.3%.The male age was 62.37±12.28 years and the female age was 63.68±9.81 years,The sexual bmi was 23.41±2.18(kg/m~2),the female body mass index was 22.89±3.33(kg/m~2).There were 6 cases of KOA cartilage injury in grade 1 patients with Recht classification,11 cases in grade2,10 cases in grade 3,and 3 cases in grade 4 in Recht classification.in30 patients with knee arthritis,there were 5 patients with normal bone density,accounted for 16.7%;and there were 6 cases of bone mass loss,accounted for 20%,,there were 19 cases of osteoporosis,accounting for63.3%.2.According to the test and chi-square test,there was no differences in age,body mass index and cartilage grading between male KOA patients and female patients with knee osteoarthritis(p>0.05,not statistically significant).3.Spearman correlation analysis showed that the r value of bone mineral density and cartilage damage was-0.882,p<0.05,indicating a negative correlation between the two,which was statistically significant.With cartilage injury as the dependent variable,gender,age,body mass index and bone mineral density T value as independent variables,further linear regression analysis was performed.It was found that there was a linear regression relationship between bone mineral density and cartilage injury,p<0.05,which was statistically significant.4.Linear regression analysis was conducted with bone mineral density as the dependent variable and gender,age and body mass index as the independent variables.The values of age and bone mineral density were-0.055,gender and bone mineral density were-1.048,p<0.05,which was statistically significant.he values of body mass index(Body mass index)and bone mineral density were 0.010,p=0.886>0.05,indicating no correlation between the two and no statistical significance.Gender and age are related to bone density.Conclusion:1.There was a negative correlation between bone mineral density T value and cartilage injury grade.that is,there was a positive correlation between osteoporosis and knee osteoarthritis.2.Gender and age are related to bone mineral density T value.Among them,age was negatively correlated with bone mineral density,In addition,women are more likely to develop osteoporosis than men.These results suggest that postmenopausal women are at high risk of osteoporosis.3.Body mass index may be a risk factor for Knee osteoarthritis and osteoporosis,but the specific mechanisms need to be further studied.4.In the early stage of KOA,the prevention and treatment of KOA by improving bone mineral density was feasible.The theory of hepatorenal homology could be used as the theoretical basis for the prevention of KOA and OP,which is worthy of further study.