| Objective:Analyzing the epidemiology and clinical characteristics of children with positive and negative Henoch-Schonlein purpura(HSP)of Mycoplasma pneumoniae(MP)to explore the impact of MP infection on HSP.It provides theoretical basis for early clinical detection and early intervention,thereby reducing the recurrence of HSP and the chance of kidney damage.Methods:A retrospective analysis was performed on 97 children with complete clinical data from January 1,2017 to January 1,2019,who were admitted to the Pediatric Department of Suizhou Central Hospital.There were 63 boys and 34 girls in the sample,with a male to female ratio of 1.85: 1 and an average age of 6.66±2.79 years old.According to whether HSP children were combined with MP infection,they were divided into an infected group and a non-infected group.Among them,33 cases were in the infected group,19 boys and 14 girls,with an average age of 6.58±2.91 years old.64 cases were in the non-infected group,44 boys and 20 girls,with an average age of 6.70±2.76 years old.The gender,age,seasonal distribution,clinical symptoms(digestive tract,joint,kidney symptoms)and related laboratory indicators of the two groups of children were statistically analyzed to find whether the two groups were different in the above aspects.According to the incidence of HSP,the children were divided into the initial group and the relapse group and a comparison of the MP positive rate between the two groups was established.Among them,65 cases were in the initial group,12 cases MP positive and 53 cases MP negative,and the MP positive rate was 18.46%.There were 32 cases,21 cases MP positive and 11 cases MP negative,and the MP positive rate was 65.63%.According to the results of routine urine test at the first time after admission,the HSP children were divided into the abnormal urine group(24-hour urine protein ration 150 mg > or urine red blood cells≥3)and the normal urine group(24-hour urine protein ration <150mg or urine red blood cells <3).And a comparison of the MP positive rate between the two groups was established.Among them 41 cases were in the urinary abnormal group,21 cases MP positive and 20 cases MP negative,and the MP positive rate was 51.22%.56 cases were in the normal urine group,including 12 MP positive and 44 MP negative and the MP positive rate 21.41%.Results:The positive rate of MP infection in 97 children with HSP was 34.02%,including 63 boys and 34 girls,with a male to female ratio of 1.85: 1.And the age of onset was more common in 5-8 years old.Both the infected group and the non-infected group indicated that there were more boys than girls.The children in both groups developed the disease throughout the year.Among them,the infected group had a high incidence in winter and spring,and the non-infected group had a high incidence in autumn and winter.There was no statistically significant difference in gender,age of onset and seasonal distribution between the two groups(P>0.05).The clinical manifestation of the infection group is that the incidence of mixed purpura is significantly higher than that of the non-infection group with statistically significantly different(P<0.05).In the comparison of laboratory results,the levels of peripheral blood ESR and β-microglobulin in the infected group were significantly higher than those in the non-infected group with statistically significantly different(P<0.05).However,there was no statistically significant difference in WBC,N,CRP,ALT levels between the two groups(P>0.05).The level of Ig A in the infected group was significantly higher than that in the non-infected group,with statistically significantly different(P<0.05).The C3 level in the infected group was significantly lower than that in the non-infected group with statistically significantly different(P <0.05).The positive rate of MP infection in the relapse group was significantly higher than that in the initial group with statistically significantly different(P<0.05).Besides,the positive rate of MP infection in the abnormal urine group was significantly higher than that in the normal urine group,and the two groups were statistically significantly different(P<0.05).Conclusion:The clinical manifestations of children with HSP infected by MP are more complex and changeable,and it is common to accumulate damage to two or more organs.Mycoplasma pneumoniae infection may be one of the risk factors for prolonged HSP.Mycoplasma pneumoniae infection may lead to the aggravation of immune dysfunction in children with HSP,resulting in early renal involvement... |
