Analysis Of Shared Syndrome And Gene Network Of Diseases Related To Adverse Childhood Experiences

Childhood trauma experience is one of the vital risk factors of psychosis and physical illness in adulthood.These experiences involve sexual abuse,physical and emotional violence or neglect,and the loss of parents and relatives.In our society,the bad experience in the early years is mainly in the form of left-behind children(maternal separation).In a survey covering all forms of abuse in Germany,27.7%of adults said that they had experienced at least one form of abuse in their childhood,23.7%reported two forms of abuse,and 16.6%reported three or more forms of abuse.A good deal of epidemiological and clinical studies have shown that there is a close relationship between the degree of negative stress experienced in childhood and the occurrence of various diseases in adulthood.There is no discussion about Early-life stress in the theory of traditional Chinese medicine,but the research group believes that children are the body of Shaoyang,and Yang Qi is easily damaged to form Yang deficiency constitution,which is related to the increased susceptibility of children to various diseases in adulthood.Modern research on the syndrome of diseases related to early years’ bad experience is still in a blank stage.The previous experimental study of the research group found that compared with the normal group,the mother infant separation mice have depression like behavior.After administration of Wenyang Jieyu formula,the depression like behavior of the mother infant separation mice can be improved.According to the formula,early years’ bad experience may lead to the formation of Yang deficiency syndrome.Some studies have found that Early-life stress can enhance the susceptibility of a variety of diseases.Because these diseases have the same pathogenic factor,they may have a common pathogenesis,so it is speculated that these diseases may have different diseases with the same syndrome.Different diseases with the same syndrome means that different diseases have the same pathogenesis,thus showing the same syndrome.Through the observation of natural,social environment,physique,lifestyle and other factors,resulting in different diseases,because the above similar factors finally form the same pathogenesis and syndrome.Therefore,this paper attempts to explore the common syndromes of diseases related to Early-life stress from the perspective of different diseases with the same syndrome,so as to explore the biological basis of common syndromes,and provide some theoretical suggestions for clinical prevention and treatment of diseases related to Early-life stress.In the first part of this study,Through PubMed database to search the clinical literature related to early adverse experience,and to sort out the literature,there are 46 diseases related to early adverse experience.divided into 13 systems according to ICD-10 disease system,and Finally,9 diseases were screened from 13 systems,namely depression,breast cancer,obesity,sleep disorders,hypertension,irritable bowel syndrome,asthma,epilepsy,SLE;The second part of this article mainly studies the distribution of TCM syndromes related to early adverse experiences.The research methods mainly searched the literature on the distribution of syndromes of depression,breast cancer,obesity,sleep disorders,hypertension,irritable bowel syndrome,asthma,epilepsy,and systemic lupus erythematosus through CNKI.After standardizing the name of the syndrome,the syndrome summary statistics are finally performed,and the common syndrome of the disease related to the early adverse experience is the syndrome of kidney-yang deficiency.the most common The syndrome was liver Qi depression.The third part of this article mainly studies the gene network of the shared syndromes of early adverse experiences.The research method mainly retrieved and downloaded the genes involved in depression,breast cancer,obesity,sleep disorders,hypertension,irritable bowel syndrome,asthma,epilepsy,systemic lupus erythematosus through GENECARD database,NCBI database respectively,then we got the intersection genes of the nine diseases and finally performed the gene network through the intersection genes of the nine diseases with the help of David database platformanalysis.The results showed that there were 273 intersection genes of adverse experience related diseases in early life,among which go enrichment analysis showed that biological processes take part in positive regulation of RNA polymerase 2 promoter transcription,immune reaction,inflammatory reaction,negative regulation of apoptosis process,etc.,cellular composition involved in the plasma membrane,extracellular space,cytoplasm,etc.,molecular functions involved in protein binding,enzyme binding,cytokine activity,etc;The KEGG enriched pathways mainly involved toll like receptor signaling pathway,cytokine receptor interaction pathway,TNF signaling pathway.By teasing through the literature on disorders associated with early life adverse experiences,as well as analyzing the literature related to the distribution of disease syndromes and the common syndrome gene network analysis of early life adverse experiences,we draw the following conclusions:1.Early life adverse experience related disorders involve multiple systems and are dominated by disorders of the psychobehavioural class of systems,the common disorder of which is depression.2.The common syndrome of adverse experience related diseases in early life is kidney yang deficiency syndrome,and the common syndrome is liver depression and qi stagnation syndrome.3.Adverse experiences in early life shared syndromes part of the underlying biological basis of kidney yang deficiency may relate to the body’s immune inflammation,and it mainly involves toll like receptor signaling,TNF signaling,and cytokine-cytokine interaction receptor signaling.