Diagnostic Value And Application Of Circulating Tumor Cells In Prostate Cancer

Objectives:As one of the most common urology cancer,the early diagnosis of prostate cancer is crutial.To explore the diagnostic value of peripheral blood circulating tumor cells(CTC)for prostate cancer,the predictive value of combined multi-parameter magnetic resonance imaging(mpMRI)for benign and malignant puncture results in patients with PI-RADS score 3 and the difference of CTC among different prostate cancer risk groups.Methods:Retrospective analysis of 80 patients with prostate cancer due to prostate specific antigen((Prostate Specific Antigen,PSA)elevation,anal finger examination((Digital Rectal Exam,DRE)touching prostate sclerosis,and imaging indication of prostate cancer.After admission to the hospital to improve the mpMRI and PSA data,peripheral blood was drawn for CTC detection,and ultrasound-guided prostate biopsy was performed.The pathological results(TNM stage and Gleason score)were obtained,and the patients were divided into two groups(BPH patients were set as the control group).After the PCa patients were set up as the experimental group,statistical studies were carried out to explore the diagnostic value of CTC in all patients with prostate cancer waiting to be discharged and patients with PSA gray area,the results of puncture positive rate in patients with PI-RADS3 combined with mpMRI,and the differences of CTC in patients with different PCa risk groups.Results:A total of 80 newly diagnosed patients were included in the study,including 26 patients in the control group BPH group and 54 patients in the experimental group PCa group.There were significant differences in the values of TPS A and CTC between the two groups.The sensitivity and specificity of diagnosis were 71.4%and 92.3%respectively(P<0.001).For the patients with PSA gray area,there was no significant difference in PSA and CTC between the control BPH group(n=20)and the experimental group PCa group(n=18).Among the patients with combined mpMRI PI-RAD S3,there was no significant difference in PSA between the control group BPH group and the experimental group PCA group.The average CTC of the BPH group was 0.70±1.059/5ml,and the average CTC of the PCA group was 3.80±3.636/5ml.There was a significant difference between the two groups.According to Gleason score,T stage and PSA,54 patients with PCa were divided into low risk group(n=8),middle risk group(n=16)and high risk group(n=30).The average PSA of the three groups was 1.25±1.16,5.13±4,80,12.07 ± 14.95cells/5ml,respectively.There was significant difference in CTC among the three groups(P<0.05).It is suggested that there is a correlation between PCa risk group and CTC count.Conclusions:1.There is a significant difference in the level of CTC between patients with tumors and patients with benign lesions,CTC can be used to help diagnose benign and malignant prostate diseases,but for patients with PSA in gray area,CTC has no obvious diagnostic value.2.There is a difference in CTC between the BPH group and the PCa group with PI-RADS score 3,indicating that CTC combined with mpMRI can make a more accurate diagnosis of PCa patients.3.The level of CTC is different in different prostate cancer risk groups,which can be combined with the existing risk group grouping criteria to get better grouping results,which is beneficial to the individualized treatment of patients.