Comparison Of Risk Factors For Recurrence Of Ulcerative Colitis In Different TCM Syndromes

Objective: To explore the risk factors related to recurrence of UC,and analyze the clinical recurrence characteristics and differences in risk factors of UC with large intestine damp heat syndrome and spleen deficiency damp stagnation syndrome.Research can provide a basis for clinical long-term individualized treatmentMethods: From January 1,2018 to January 31,2020,UC patients who met the research criteria in the Affiliated Hospital of Shandong University of traditional Chinese medicine and Tai’an Hospital of traditional Chinese medicine were followed up one year after discharge.They were divided into recurrence group and non recurrence group.Clinical data were collected,and risk factors for recurrence were screened by univariate analysis and logistic regression analysis.The prediction value was evaluated by the working characteristic curve of the subjects.57 cases of large intestine damp-heat syndrome and 37 cases of spleen deficiency dampness stagnation syndrome were compared in the recurrence group.Results: 1.A total of 205 patients were included,149 in the recurrence group.The recurrence rate was 72.6% within one year after discharge.2.Logistic regression analysis showed severe(OR=13.843,95% CI :1.024-187.147,severity P=0.048,D-dimer elevation(ORP=4.148,95% CI:1.138-15.115 、 PP=0.031),maintenance therapy less than 1 year were independent risk factors(ORP=45.401,CI:12.651-162.930,95 per cent P<0.001).The working characteristic curve of the subjects showed that the prediction value of the model was good,among which the prediction value of maintenance treatment time was the largest.3.Dampness and heat syndrome of large intestine recurrence rate is higher than spleen deficiency dampness syndrome(P<0.05).Colorectal dampness and heat certificate is mainly moderate and severe disease,spleen deficiency and dampness resistance proof is mainly light and moderate disease.The incidence of abdominal pain and endoscopic Mayo score were higher in patients with large intestine dampness and heat syndrome than in patients with spleen deficiency and dampness obstruction syndrome,the degree of mucus and blood stool was heavy,the detection rate of white blood cells in stool was higher than 3/ HP,and the count of white blood cells and lymphocytes was higher(P less than 0.05).Compared with large intestine dampness and heat syndrome,erythrocyte,hemoglobin,and albumin decreased(P<0.05).4.The risk factors of recurrence of the two syndromes,the patients with the moderate and severe activity of large intestine damp-heat syndrome were more than those with spleen deficiency and dampness obstruction syndrome(P<0.05),and there was no difference in D-dimer and maintenance treatment time.Conclusion: To avoid recurrence,the severe illness and D-dimer elevation should be actively controlled,and the maintenance treatment time should be greater than 1 year.The recurrence rate of colorectal dampness and heat syndrome is higher than that of spleen deficiency and wet resistance syndrome,which may be related to the large proportion of patients with severe diseases.