| Background:Silent brain infarcts(SBI)played an important role in the progression of stroke in the elderly,but the relationship between it and stroke in young and middle-aged people has been less reported.Patent foramen ovala(PFO)is a common risk factor for ischemic stroke in young and middle-aged adults,however,the potential relationship between PFO and SBI in young and middle-aged adults remains unclearObjective:To determine the existence of PFO in young and middle-aged patients with SBI,and to analyze the relationship between PFO and SBI in young and middle-aged,and to understand the risk factors of young and middle-aged SBI,so as to provide basis for early identification and prophylaxes of SBI.Methods:Continuous selection in June 2018-June 2020 healthy check-up,neurology clinic patients in our hospital and hospitalized patients as the research object,and eventually according to the inclusion and exclusion criteria,a total of 159 cases,and according to the diagnostic criteria and is in compliance with the SBI craniocerebral MRI or CT results,divided into SBI group and healthy control group,108 cases and 51 cases respectively,the ages of 20 and 55,records of two groups of patients’age,sex,blood pressure,blood lipid,blood sugar,smoking history,history of drinking,homocysteine,foaming test results and the experimental data such as brain imaging.The basic data of the SBI group and the control group as well as the number of patients with PFO in the two groups were compared,and the relationship between PFO and SBI was analyzed,as well as whether PFO affected the distribution location and the 180days fouow-up.P<0.05 was considered statistically significant.SPSS26.0 software package was used to process and analyze the data,t-test was used for measuring data,X~2test was used for counting data,and logistic analysis was used for influencing factors of SBI.Results:(1)The basic data between the SBI group and the control group.In univariate analysis,the important risk factors for SBI included age(P=0.031),hypertension(P=0.007),alcohol consumption history(P=0.031),carotid intima thickening(P<0.001)and carotid artery plaque(P=0.004).Total cholesterol(P<0.001),triglyceride(P=0.001),high-density lipoprotein(P=0.005),low-density lipoprotein(P=0.046),homocysteine(P=0.032).In multivariate analysis,the independent influencing factors for the occurrence of SBI patients were the Patoforamen ovale,total cholesterol,homocysteine,and carotid intima thickness(OR>1).(2)The positive rate of PFO in SBI group was significantly higher than that in control group,with statistical difference(P<0.05).(3)Compared with the anterior circulation,the lesions in the SBI group were significantly distributed in the posterior circulation,anterior circulation and posterior circulation(P<0.05);The number of lesions tended to be multiple(P<0.05).Conclusions:(1)The prevalence of Silent cerebral infarction increased with age in young and middle-aged adults.Age,hypertension,drinking,carotid intimal thickening and carotid plaques,total cholesterol,triglycerides,high-density lipoprotein cholesterol(hdl-c),low density lipoprotein cholesterol(hdl-c),homocysteine is young and middle-aged patients with SBI disease risk factors,including patent foramen ovale,total cholesterol,homocysteine and carotid intima thickness are independent risk factors of young and middle-aged asymptomatic cerebral infarction(2)In patients who have posterior PFO,ischemic lesions are more likely to be distributed in the posterior circulation and coexistence to anterior and posterior circulation than that in anterior circulation.(3)The number of lesions tended to be multiple... |
