The Effectiveness Evaluation Of Lee Silverman Voice Treatment For Speech-language Disorders In Mid-to-late Stage Parkinson’s Disease Patients

Objective:According to research,about 90%patients have speech disorders in Parkinson’s disease.Our purpose is to compare the changes of language parameters,voice handicap index(VHI),and voice perception scale(VAS)in mid-late PD patients after modified LSVT-LOUD speech therapy,to explore the effectiveness and safety of modified LSVT-LOUD speech therapy in mid-late patients with PD.Methods:We conducted a randomized controlled study.This study recruited mid-late PD patients with speech disorders who were treated at Zhujiang Hospital of Southern Medical University and Guangdong Provincial People’s Hospital from November 2018 to December 2020.They were randomly divided into modified LSVT-LOUD rehabilitation treatment group or Control group at a ratio of 1:1.In the case of stable anti-PD drug treatment,the rehabilitation specialist will give 4 weeks of modified LSVT-LOUD treatment or no intervention treatment.During the baseline period(V0)and visit period V1,Praat voice analysis software,voice perception scale,and voice handicap index were used to evaluate the voice function of subjects to evaluate the effectiveness and safety of modified LSVT-LOUD in the PD with speech disorders.Results:1.Compared with the control group,after treatment,the improvement of the maximum duration of sustained vowel "Ah" phonation and the various voice parameters of the Voice Perception Scale were statistically different(P<0.05)in the treatment group,while there was no significant difference in the control group(P>0.05).2.After stratifying according to H&Y staging,we found that among the mid-stage(H&Y=2.5～3.0)PD patients in the treatment group,the improvement of the maximum duration of sustained vowel "Ah" phonation and VAS were statistically different(p<0.05).In patients with advanced(H&Y=4.0)PD and the control group,all indicators are not statistically different(p>0.05).Conclusion:1.After 4 weeks of anti-PD medication and modified LSVT-LOUD therapy,the patient’s maximum duration of sustained vowel "Ah" phonation and VAS have improved,suggesting that the patient’s respiratory function,voice quality,and delaying disease progression have been improved;2.The modified LSVT-LOUD treatment has a better effect on improving speech-language disorders in mid-stage PD;3.The modified LSVT-LOUD rehabilitation therapy has no adverse events on PD patients with speech-language disorders,and is safety and effectiveness.