| Objective: To explore the clinical significance of preoperative ROMA index combined with D-dimer in the diagnosis of ovarian cancer,and to provide a reference for the clinical diagnosis of ovarian cancer.Methods: A total of 93 patients with ovarian cancer diagnosed by pathology in the Affiliated Hospital of Yanbian University from January 2007 to December 2020 were selected as the ovarian cancer group,including 45 non-menopausal patients and48 postmenopausal patients.99 patients diagnosed as benign ovarian tumor by pathology were classified as benign ovarian tumor group,including 49 cases of non-menopausal and 50 cases of menopausal.The general data,carbohydrate antigen125(CA125),human epididymal protein 4(HE4),D-dimer serum levels,tumor histological types and ovarian malignant tumor stage of the ovarian cancer group and benign ovarian tumor group were collected respectively.SPSS 26.0 software was used for statistical analysis of all data,and P<0.05 was statistically significant.When comparing the differences between groups,Kruskal-Wallis non-parametric test was applied to calculate the sensitivity and specificity of each indicator.Receiver Operating Characteristic Curve(ROC)and Area Under ROC Curve(AUC)were used to evaluate the feasibility of detecting indicators in the diagnosis of ovarian cancer.Results:(1)CA125,HE4,ROMA index and D-dimer in ovarian cancer group were higher than those in benign ovarian tumor group,with statistical significance(P<0.05).(2)The D-dimer and HE4 of postmenopausal patients in benign ovarian tumor group were higher than those of premenopausal patients,with no statistical significance(P>0.05).CA125 in postmenopausal patients was lower than that in premenopausal patients,and the difference was statistically significant(P<0.05).Roma index of postmenopausal patients was higher than that of premenopausal patients,and the difference was statistically significant(P<0.05).(3)The D-dimer and CA125 of postmenopausal patients in ovarian cancer group were higher than those of premenopausal patients,with no statistical significance(P>0.05).The HE4 and Roma indexes of postmenopausal patients were higher than those of premenopausal patients,with statistical significance(P<0.05).(4)ROC curve analysis showed that the area under the curve of D-dimer,CA125,HE4 and ROMA index were 0.734,0.919,0.887 and 0.923,respectively,with statistically significant differences(P<0.05),and the critical values were 0.61,37,54.16,859.06%,respectively.The sensitivity was 45.20%,79.60%,74.20% and79.60%,respectively.The specificity was 90.90%,91.90%,86.90% and 92.90%,respectively.The areas under the ROC curve of CA125+ D-dimer,HE4+ D-dimer and ROMA index + D-dimer were 0.923,0.920 and 0.936,respectively,the differences were statistically significant(P<0.05),and the sensitivity were 82.80%,84.95% and86.02%,respectively.The specificity was 89.90%,85.86% and 92.93%,respectively.(5)CA125 and D-dimer in advanced ovarian cancer group were higher than those in early ovarian cancer group,and the difference was statistically significant(P<0.05).The HE4 and Roma indexes of advanced ovarian cancer group were higher than those of early ovarian cancer group,and the difference was not statistically significant(P>0.05).(6)ROC curve analysis showed that the area under the curve of CA125,HE4,ROMA index and D-dimer in the diagnosis of ovarian cancer alone was 0.695,0.557,0.567 and 0.652,respectively,and the difference of CA125 and D-dimer was statistically significant(P<0.05).The critical values were 579.10,260.80,9640.87%and 0.60,respectively.The sensitivity was 56.00%,28.00%,28.00%,68.00%,respectively.The specificity was 81.00%,94.00%,94.00% and 64.00%,respectively.Conclusion:(1)Preoperative Roma index combined with D-dimer can be used as a reference index for the diagnosis of ovarian cancer;(2)Roma index can be used as a reference index for the diagnosis of ovarian cancer in postmenopausal women;(3)CA125 and D-dimer can be used as diagnostic indexes of ovarian cancer staging. |
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